Cerebrospinal fluid specimens from patients with suspected meningitis were screened with the Phadebact Haemophilus Test (Pharmacia Diagnostics), with Bactogen (Wampole Laboratories), and by counterimmunoelectrophoresis. With culture-positive fluids, Phadebact coagglutination detected 95%, Bactogen latex agglutination detected 91%, and counterimmunoelectrophoresis detected only 79%. Both aggluti...

The treatment of tuberculous meningitis is frequently hindered by the formation of exudate within the cerebrospinal spaces. This exudate may obstruct the cerebrospinal circulation and give rise to the complications of subtentorial, basal cistern, and spinal block. Furthermore, the presence of exudate predisposes to the occurrence of tuberculous arteritis, which is responsible for the cerebral a...

In the course of the quantitative studies of glomerular urine which have long been in progress in this laboratory, analytical methods requiring exceedingly minute amounts of fluid have been developed for a number of constituents of blood and urine. It seemed important to extend the application of these methods to certain other body fluids for the sake not only of the information which might be ...

Since one of us (J.N.C.) in 1953 recorded the results of electrophoresis on paper of the proteins of the cerebrospinal fluid and cerebral cyst fluids a number of other supporting media have been employed for this purpose. Some, such as starch, are valuable because of a higher resolving power and a greater ability to separate many of the protein components. The use of the polyacrylamide disc ele...

Cystatin C, alias post-y-globulin or -trace protein, has been shown to be a potent inhibitor of cysteine proteinases; this protein is normally present in different biological fluids, but particularly so in cerebrospinal fluid. The concentration of cystatin C was determined by radial immunodiffusion in cerebrospinal fluid from patients affected with multiple sclerosis, patients affected* with va...

Quantitative lactate determinations were performed on cerebrospinal fluids to assess their value in the rapid diagnosis of bacterial and mycotic meningitis and to evaluate their value in assessing the prognosis in these patients. Cerebrospinal fluid lactate concentrations were elevated in all patients with untreated bacterial or fungal meningitis. Lactate concentrations proved very valuable in ...

The detection of circulating galactomannan in serum is an important tool for the early diagnosis of invasive aspergillosis. A commercial enzyme-linked immunosorbent assay (Platelia Aspergillus; BioRad) was shown to be both highly sensitive and specific for detection of galactomannan in serum samples. Despite the fact that this assay is validated for serum samples, specimens of other body fluids...

background viral meningitis is an inflammation of the leptomeninges as a manifestation of central nervous system (cns) infection. more than 85% of viral meningitis cases are caused by non-polio enteroviruses. this is the first study on the description of the enteroviruses and the related serotypes involved in viral meningitis in iran. objectives this project was conducted to improve our knowled...