In this paper we propose a new diagnostic feature for Alzheimer's Disease (AD) which is based on assessment of the degree of inter-hemispheric asymmetry using Single Photon Emission Computed Tomography (SPECT). The asymmetry measure used represents differences in 3D perfusion image patterns in the cerebral hemispheres. We start from the simplest descriptors of brain perfusion such as the mean i...

Moyamoya disease can be associated with a rapidly progressive course in young patients. This report describes a patient with moyamoya disease who experienced rapid disease progression, resulting in cerebral infarction and a wide area of diminished cerebral perfusion. Double superficial temporal artery (STA)-middle cerebral artery (MCA) anastomoses were utilized to immediately increase cerebral ...

Landau-Kleffner syndrome (LKS) is a rare childhood disorder characterized by acquired aphasia and epilepsy. 99mTc-ECD SPECT imaging was performed in two right-handed children with LKS. A relative decrease in perfusion was found in the left frontal-temporal cortices of both patients as well as in the left and right parietal cortices of one patient with aphasia, without clinical epilepsy. The deg...

UNLABELLED Emotional and cognitive abnormalities are common in adult hypothyroidism. Few studies, however, have evaluated cerebral perfusion and metabolism in this disorder. The aims of this study were to compare regional cerebral blood flow (rCBF) between hypothyroid patients and healthy subjects and assess flow during the euthyroid state after treatment. METHODS Ten mildly hypothyroid patie...

OBJECTIVE To investigate the influence of the presenilin-1 gene (PS-1) mutation on regional cerebral perfusion, SPECT was evaluated in 57 individuals. The subjects were members of a large pedigree from Colombia, South America, many of whom carry a PS-1 mutation for early-onset AD. METHODS Members of this large kindred who were cognitively normal and did not carry the PS-1 mutation (n = 23) we...

introduction: attenuation correction is a useful process for improving myocardial perfusion spect and is dependent on activity and distribution of attenuation coefficients in the body (attenuation map). attenuation artifacts are a common problem in myocardial perfusion spect. the aim of this study was to compare the effect of attenuation correction using different attenuation maps and different...

background: diagnosis of coronary artery disease (cad) in patients with left bundle branch block (lbbb) is considered as a challenge in cardiology due to the low accuracy of noninvasive methods such as basal and stress electrocardiography (ecg). this diagnostic challenge can be reduced but not eliminated using dipyridamole as a stress method instead of exercise. the aim of this study was to ass...

UNLABELLED This study examined the relationship between the severity of aphasia and regional cerebral perfusion on brain SPECT using statistical parametric mapping (SPM) and a statistical probabilistic anatomic map (SPAM) in patients with a striatocapsular infarction (SCI) along with the other clinical and imaging findings. METHODS The subjects were 16 right-handed Korean-speaking patients wi...

BACKGROUND The present study was carried out to evaluate cerebral perfusion in multiple sclerosis (MS) patients with a moderate to severe stage of disease. Some patients underwent hyperbaric oxygen therapy (HBOT) and brain perfusion between before and after that was compared. METHODS We retrospectively reviewed 25 secondary progressive (SP)-MS patients from the hospital database. Neurological...

introduction: studies with single photon emission computed tomography (spect) have revealed inconsistent changes of regional cerebral blood flow (rcbf) in schizophrenia. some studies investigated the rcbf and its relationship with psychopathology, positive and negative symptoms in treated patients. however, there is a little information about the pattern of rcbf in recently untreated or never t...