Abstract Central nervous system (CNS) involvement remains a challenge in the diagnosis and treatment of acute lymphoblastic leukemia (ALL). In this study, we identify CD79a (also known as Ig?), signaling component preB cell receptor (preBCR), to be associated with CNS-infiltration –relapse B-cell precursor (BCP)-ALL patients. Furthermore, show that downregulation hampers engraftment cells diffe...

introduction: burkitt lymphoma (bl) is rare, but an aggressive malignancy. central nervous system burkitt lymphoma (cnsbl) is very rare. cns burkitt’s lymphoma is treated with high-dose chemotherapy and radiation. radiotherapy in children younger than three years old may cause major cns damage. case report: a three-year-old boy presented with painful proptosis of the left eye. he underwent aden...

depression is a mental disorder that results from changes in the central nervous system (cns) that may result from immunological abnormalities. according to the world health organization, major depression will become the leading cause of disability worldwide. accumulating evidence has indicated the existence of reciprocal communication pathways between nervous, endocrine and immune systems. the...

abstract objective the great majority of patients with childhood leukemia become long-term survivors. they treated with chemotherapy and prophylactic central nervous system (cns) irradiation. the aim of this cross-sectional study was to evaluate effect of the long-term toxicity in all survivors, and possible effects of this treatment on their intellectual in compare with their sibling. material...

The paper presents one of the options for automating evaluation procedures magnetic resonance imaging (MRI) brain in patients suffering from most severe diseases central nervous system (CNS), multiple sclerosis.

  Sarcoidosis is a multisystem noncaseating granulomatous disease with a propensity for lung, eye, and skin which recently have been proposed that mycobacterium tuberculosis may contribute in its pathogenesis, and rarely involves central nervous system (CNS). Despite CD4+ lymphocytopenia, sarcoidosis by itself does not increase risk of opportunistic infections other than cryptococcosis.Nonethel...

amitraz is a triazapentadiene, an α2 adrenergic agonist and a member of the amidine chemical family. a limited number of human intoxication cases have been published in the literature. lack of a clear and specific protocol for the therapy of amitraz intoxication may make its successfully managed case reports useful and valuable for other clinical practitioners in poisoning departments. the case...

fructose consumption has increased dramatically in the last 40 years, and its role in the pathogenesis of the metabolic syndrome has been implicated by many studies. it is most often encountered in the diet as sucrose (glucose and fructose) or high-fructose corn syrup (55% fructose). at high levels, dietary exposure to fructose triggers a series of metabolic changes originating in the liver, le...

neuroinflammation as a protective mechanism for repairing tissue damage in the central nervous system (cns), has been classified into two types: acute and chronic. it is characterized by the activation of microglia and astrocytes and the increase levels of different chemokines and cytokines. neuroinflammation can be harmful, and it is a common pathological feature in neurodegenerative and psych...