Lipid nanoparticle is one of the dosage forms that have a particle size 1-100 nm. systems aggregation causes an increase in with storage time so carrier needed can reduce aggregation. The lipid system formulated gel preparations add to matrix thereby reducing Central Composite Design (CCD) part experimental design Response Surface Methodology be used determine optimization gelling agents and hu...

This study investigates the optimal conditions for preparation of corn cob based activated carbon (CCAC) for the removal of Remazol Brilliant Blue R (RBBR) reactive dye from aqueous solution. The CCAC was prepared by using physiochemical activation method which consisted of sodium carbonate (Na2CO3) and CO2 gasification. Central composite design (CCD) was used to determine the effects of the th...

Methodology Active packaging material was low density polyethylene (LDPE) film incorporated with Tinuvin 326(UV absorber) and iron powder in different concentrations (0-0.5% and 0-15% w/w, respectively). Eleven treatments were performed according to the central composite design (CCD) in order to evaluate changes in mechanical, physical and barrier properties of films. Moreover, the influence of...

An HS-SPME method was developed using multivariate experimental designs, which was conducted in two stages. The significance of each factor was estimated using the Plackett-Burman (P-B) design, for the identification of significant factors, followed by the optimization of the significant factors using central composite design (CCD). The multivariate experiment involved the use of Minitab® stati...

a method was developed for removal, preconcentration and spectrophotometric determination of trace amounts of methyl red based on sio2-coated fe3o4magnetic nanoparticles. the influence of ph, dosage of adsorbent and contact time on the adsorption of dye was explored by central composite design. the kinetic data were analyzed based on the langmuir and freundlich adsorption isotherms. the langmui...

bacillus subtilis k40b was isolated from rice rhizospheres and its potential for production of xylanase was evaluated using biochemical methods. the gene for xylanase in b. subtilis k40b was amplified, sequenced and assigned to the ncbi genebank. the gene size was estimated to be 563 bp encoding 413 amino acids. comparison of the xylanase gene with reference sequences showed that the xylanase o...

Biodiesel was prepared from Xanthoceras sorbifolium Bunge oil and methanol by transesterification with NaOH as the catalyst. The central composite design (CCD) utilized to optimize its process, Design Expert software applied perform a fitting regression. best process conditions were determined as: 0.9%, molar ratio of 7:1, reaction temperature 62 °C. Under these conditions, yield biodiesel 89.0...

Central composite discrepancy (CCD) has been proposed to measure the uniformity of a design over irregular experimental region. However, how CCD-based optimal uniform designs can be efficiently computed remains a challenge. Focusing on this issue, we proposed a particle swarm optimization-based algorithm to efficiently find optimal uniform designs with respect to the CCD criterion. Parallel com...

objective(s): response surface methodology (rsm) by central composite design (ccd) was applied to statistically optimize the preparation of rutin-quercetin (ru-qr) dual drug loaded human hair keratin nanoparticles as well as evaluate the characteristics. materials and methods: the effects of three independent parameters, namely, temperature (x1:10-40 c), surfactant (x2: sds (1), sls (2), tween-...