The in vitro and vivo toxicity of copper oxide nanoparticles (CuO NPs) is attributed to both particle dissolved ion species. However, a clear understanding (1) the specific cellular responses that are modulated by two species (2) temporal dynamics toxicity, as proportional amount particulate ionic forms change over time, lacking. In current study, microparticulate CuO MPs), NPs, Cu2+ were chara...

Iron constitutes a major source of toxicity due to its ability to generate reactive oxygen species that can damage cellular macromolecules. However, the precise mechanism by which exposure to high iron concentrations results in cellular toxicity remains unknown. Here we identify sphingolipid synthesis and signaling as a major mediator of iron toxicity in S. cerevisiae. Inhibition of sphingolipi...

At present, nanofilaments are not exclusively based on carbon atoms but can be produced from many inorganic materials in the form of nanotubes and nanowires. It is essential to systematically assess the acute toxicity of these newly synthesized materials since it cannot be predicted from the known toxicity of the same material in another form. Here, the cellular toxicity of TiO2-based nanofilam...

although the biokinetics, metabolism, and chemical toxicity of atorvastatin calcium are well known, until recently little attention was paid to the potential toxic effects of atorvastatin calcium on re-production and development in mammals. in recent years, it has been shown that atorvastatin calcium is a developmental toxicant when given orally or subcutaneously (sc) to mice. decreased fertili...

Increased production and use of nanomaterials has led to an ever growing exposure of living organisms tothese substances. Limited knowledge about possible toxicity of nanomaterials and their potential to harmliving creatures is becoming a serious concern. To address this problem, there is a need for development ofdiagnostic methods enabling effective determination of potential toxicity of nanom...

objective: although much is known about estrogen and progesterone, their toxicity or protective effects on hepatocytes are yet to be fully understood. this study investigated the probable oxidant or antioxidant effects of estrogen and progesterone on hepg2 cell line in the presence or absence of h2o2. methods: hepg2 cells were cultured with two concentrations of estrogen and progesterone (10pm ...