Objective(s): The use of antisense oligonucleotides (AOs) to restore normal splicing by blocking the recognition of aberrant splice sites by the spliceosome represents an innovative means of potentially controlling certain inherited disorders affected by aberrant splicing. Selection of the appropriate target site is essential in the success of an AO therapy. In this study, in search for a splic...

micrornas (mirnas) represent a class of small non-coding rna molecules that regulate gene expression at the post-transcriptional level. they play a crucial role in diverse cellular pathways. ionizing radiation (ir) is one of the most important treatment protocols for patients that suffer from cancer and affects directly or indirectly cellular integration. recently it has been discovered that mi...

landsat data for 1992, 2000, and 2013 land use changes for ekbatan dam watershed was simulated through ca-markov” model. two classification methods were initially used, viz. the maximum likelihood (mal) and support vector machine (svm). although both methods showed high overall accuracy and kappa coefficient, visually mal failed in separating land uses, particularly built up and dry lands.there...