نتایج جستجو برای: cellular microenvironment
تعداد نتایج: 462140 فیلتر نتایج به سال:
The mammalian cellular microenvironment is shaped by soluble factors and structural components, the extracellular matrix, providing physical support, regulating adhesion and signalling. A global, quantitative mass spectrometry strategy, combined with bioinformatics data processing, was developed to assess proteome differences in the microenvironment of primary human fibroblasts. We studied secr...
Ischemic cardiovascular disease, including myocardial infarction and heart failure, is among the primary causes of death worldwide. Therapies utilizing stem cells for cardiovascular regeneration in humans represent promising strategies to treat cardiovascular disease. In the adult heart, the hypoxic microenvironment typical of pathological conditions such as heart failure and myocardial infarct...
inflammatory condition is the consequence of defensive mechanism of immune system against viral and bacterial infection, tissue injury, uv radiation, stress and etc. persistently acute inflammation leads to chronic phase which is characterized by production of pro-inflammatory mediators from t cells. these molecules (e.g. il-6, tnf-α, il-1β and il-17) are mostly pleiotropic cytokines involved i...
The brain microenvironment deeply differs from the of any other organ. is, in fact, characterized by distinct metabolic conditions and immune environment, it is composed unique cell types such as neurons cells glia, like astrocytes microglia. Increasing evidence suggests that plays an important role pathogenesis tumors metastases. However, how human niche interacts with eventually remodeled pri...
Glycoconjugates and their programmed changes during the course of development in the cell-surface as well as in the extracellular matrix, are known to affect cell differentiation, cellular interaction and other developmental phenomena during embryogenesis. The purpose of this study was to localize N-acetylgalactosamin as well as fucose-containing glycoconjugates in situ during thymus developmen...
Potentially carcinogenic compounds may cause cancer through direct DNA damage or through indirect cellular or physiological effects. To study possible carcinogens, the fields of endocrinology, genetics, epigenetics, medicine, environmental health, toxicology, pharmacology and oncology must be considered. Disruptive chemicals may also contribute to multiple stages of tumor development through ef...
Abstract While genetic changes are critical for the malignant transformation of epithelial cells, the microenvironment in which the cells reside also governs carcinogenesis. Most tumors arise within a cellular microenvironment characterized by suppressed host immunity, dysregulated inflammation, and increased production of cellular growth and survival factors that induce angiogenesis and inhibi...
umbilical cord blood (ucb) as a source of hematopoietic stem/progenitor cells (hspcs) used for umbilical cord blood transplantation (ucbt). the main obstacle in application of this source as an appropriate source of hspcs is low volume of this product. so ex vivo expansion of these cells in a microenvironment which mimic body condition is important. in current study we designed biocompatible mi...
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