If there is any primary rule of science, it is . . . acceptance of the obligation to acknowledge and describe all of re a l i ty, all that exists, e ve rything that is the case. . . . it must accept within its jurisdiction e ven that which it cannot understand or explain, that for which no theo ry exists, that which cannot be measured, predicted, controlled, or o rd e red. . . . It includes all...

Stroke, is accounting for more than 34% of total healthcare spending globally. Ischemic stroke (IS) accounts for 62.4% of incident stroke cases. IS-related direct medical expenditures place a considerable burden on healthcare system. The burden is more prominent in developing countries where limitations in insurance coverage is a big concern. It would be less challenging in developed countries,...

background glioblastoma is a type of brain tumor with poor response to available therapies, and shows high rate of mortality. despite remarkable advancements in our knowledge about cytogenetic and pathophysiologic features of glioblastoma, current treatment strategies are mainly based on cytotoxic drugs; however, these therapeutic approaches are facing progressive failure because of the resista...

a male patient with acute renal failure (arf) due to large b-cell non-hodgkin lymphoma infiltration of kidney is presented. the diagnosis was suspected because of coincidence of arf and tumor lysis syndrome non-responsive to conservative renal therapies. a renal biopsy confirmed diagnosis and appropriate chemotherapy led to complete improvement of renal function.

There is currently great interest in the development of cell-based therapies, particularly those focused on idea exploiting systemically administered immune cells for therapeutic purposes cancer (e.g., CAR-T and CAR-NK cells). The ability to monitor fate vivo after administration vital assessment outcomes therapies both preclinical research clinical practice. In this context, imaging techniques...

traumatic brain injury (tbi) is described as a situation in which the brain is damaged by an external force. it is considered to be a chief problem in health care. pharmacotherapy and stem cell therapy are the main treatments used in tbi. the purpose of these procedures is to control the inflammation in injured regions of brain. currently, there is no effective care for tbi that could regenerat...