The T-cell receptor (TCR) is required for maturation and function of regulatory T cells (Tregs), but the ligand specificities of Tregs outside the context of transgenic TCRs are largely unknown. Using peptide-MHC tetramers, we isolated rare specific Foxp3+ cells directly ex vivo from adult peripheral blood and defined their frequency and phenotype. We find that a proportion of circulating Tregs...

The consequences of regulatory T cell (Treg) inhibition of interleukine 2 secretion is examined by mathematical modelling. We demonstrate that cytokine dependent growth exhibits a quorum T cell population threshold that determines if immune responses develop on activation. Secretion inhibition manipulates the growth dynamics and effectively increases the quorum threshold, i.e. to develop immune...

Population balance modeling has received an unprecedented amount of attention during the past few years from both academic and industrial quarters because of its applicability to a wide variety of particulate processes. In this article, a fresh look is taken of the basic issues of the application of population balances towards strengthening the approach as well as widening the scope of their ap...

the concept of imagery is to make an image of successful movement skill or a relaxing image in mind with no body training and external experience. the aim of the present study was to compare the effect of traditional and pettlep mental imagery methods on static and dynamic balance. the statistical population consisted of all female university of tehran students who had general physical educatio...

The population balance equation is used to describe the dynamics of a continuous crystallizer. A simple condition to guarantee the stability of a mixed suspended mixed product removal crystallizer is derived based on the population balance. A novel discretization scheme solves the population balance and the resulting discretized population balance is shown to be equivalent to the original popul...

In this work we develop, demonstrate, and distribute the code for a new Simulink block that models the dynamic evolution of the population density function for a physical system which can be modeled by a population balance equation. The name of the block is PCSS, for population balance modeling using the conservation element/solution element method in Simulink. The block interfaces with an auxi...

Multidimensional population balance models (PBMs) describe chemical and biological processes having a distribution over two or more intrinsic properties (such as size age, independent spatial variables). The incorporation of additional variables into PBM improves its descriptive capability can be necessary to capture specific features interest. As most PBMs interest cannot solved analytically, ...