Granzyme M (GM) is a novel serine protease whose expression is highly restricted to natural killer (NK) cells, CD3 CD56 T cells, and T cells. Using a GM-specific monoclonal antibody, we analyzed the expression of GM in 214 mature T-cell and NK-cell lymphomas. GM was preferentially expressed in nasal NK/T-cell lymphomas (100%), T-cell lymphomas (100%), and intestinal T-cell lymphomas (85%). In c...

BACKGROUND Lymphomas represent the fifth most frequent cancer in Lebanon. However, little is known concerning epidemiologic characteristics and distribution of lymphoid neoplasms according to the 2008 WHO classification. MATERIALS AND METHODS We conducted a retrospective study of lymphoma cases diagnosed from 2008 till 2012 at Hotel-Dieu de France University Hospital. RESULTS A total of 502...

AIMS Fine needle aspiration (FNA) cytology is an accepted means of diagnosing and typing common forms of lymphoma, particularly small lymphocytic lymphoma, follicular lymphoma, and large B cell lymphoma. However, its usefulness for diagnosing less common forms of lymphoma is not clearly established and this study was designed to examine this. METHODS The study reviewed the FNAs of suspected l...

Fifty canine lymphomas were classified cytomorphologically using the updated Kiel classification scheme. Aspirates of lymph nodes from dogs with lymphoma were stained using 5 canine-specific antibodies and 3 human-specific antibodies that cross-react with canine lymphocytes. The antibody-stained aspirates were analyzed by flow cytometry. A total of 32 (64%) of the 50 lymphomas were characterize...

The incidence of primary cutaneous lymphomas in the European Union reaches 1/100 000 per year. Primary cutaneous lymphomas originate in the skin and they are restricted to the skin. Secondary cutaneous lymphomas are manifestations of lymphomas of nodal or extranodal origin. Primary cutaneous lymphomas include various lymphoproliferative disorders: 65% are cutaneous T-cell lymphomas (CTCL), 25% ...

In order to compare the prognoses of patients with diffuse malignant lymphomas on the basis of histology and immunophenotypes, we retrospectively studied 62 cases of diffuse lymphoma arising in lymph nodes. We also evaluated the reactivity patterns of monoclonal antibodies (MoAb) LN1, LN2 and LN3 to determine the criteria for making a differential diagnosis in B cell lymphomas. The immunologic ...

two hundred and ninety cases of non-hodgkin's lymphoma from the fars province cancer registry and mashad university hospital were reviewed and classified according to the new international working formulation for clinical use. the cases fall into low-grade (35 male, 26 female), intermediate-grade (61 male, 26 female), and high-grade (84 male, 26 female) groups. each group includes several ...