Apoptotic cell death has been shown to contribute to neurodegeneration. Two biochemical processes are thought to be obligatory in apoptosis, namely, the activation of the caspases and the fragmentation of nuclear DNA. The purpose of this study was to investigate the mechanisms of DNA disintegration during neuronal apoptosis and to clarify whether HMWand internucleosomal DNA cleavage represent d...

The aim of this study was to investigate if the changes made in the specifications of the disintegration procedure impact the performance of the disintegration test described in USP chapters <701> and <2040>. Different tablets and capsules were produced, and their disintegration times were determined. The following disintegration time parameters were analyzed: volume of the immersion fluid, typ...

A molecular systematic study of Scrophulariaceae sensu lato using DNA sequences of three plastid genes (rbcL, ndhF, and rps2) revealed at least five distinct monophyletic groups. Thirty-nine genera representing 24 tribes of the Scrophulariaceae s.l. (sensu lato) were analyzed along with representatives of 15 other families of Lamiales. The Scrophulariaceae s.s. (sensu stricto) include part or a...

Conditional probability distributions seem to have a bad reputation when it comes to rigorous treatment of conditioning. Technical arguments are published as manipulations of Radon±Nikodym derivatives, although we all secretly perform heuristic calculations using elementary de®nitions of conditional probabilities. In print, measurability and averaging properties substitute for intuitive ideas a...

The radiations from 60-day Sb lN have been studied by several investigators. H ales and Jordan [2] used a 1800 spectrometer to study the beta spectrum of Sb124. Tbey report the presence of two components with maximum cnergies at 0.74 ± O.03 and 2.45 ± 0.07 million electron volts (NIev) . ~1iller and Omtiss [3], u ing a thin magnetic len spectrometer , also ob erved a complex beta specLrum, but ...