Extended-spectrum beta-lactamases (ESBLs), mainly of the CTX-M family, have been associated with Escherichia coli strains of animal origin in Europe. An in vivo experiment was performed to study the effects of veterinary beta-lactam drugs on the selection and persistence of ESBL-producing E. coli in the intestinal flora of pigs. Twenty pigs were randomly allocated into three treatment groups an...

The aim of this study was to investigate the distribution cefquinome in different dairy products during processing naturally contaminated milk or spiked milk. analysis residues milk, skimmed buttermilk, whey, cream, butter, curd, and cheese samples performed using a water:acetonitrile solvent extraction C18 dispersive solid-phase (d-SPE) clean-up, followed by ultrahigh-performance liquid chroma...

Prevention of antibiotic residues in milk is an important aspect in milk production to ensure health protection for the consumer and high quality of milk for dairy processing. Limited information is available on the potential impact of milking frequencies associated with Automatic Milking (AM) on excretion of veterinary drugs in milk. Under experimental conditions the excretion of antibiotics i...

therapy without antibiotics. Finally, the hypothesis for MRSA being selected by the use of cefquinome in those horses cannot be excluded. In this study, two CCs with no geographical clustering were characterized. Indeed, three MRSA strains belonged to CC130, the most prevalent CC among mecC-positive MRSA in animals, whereas the fourth one belonged to ST49, which was recently described in mecC-p...

BACKGROUND Haemophilus parasuis (H. parasuis) causes Glässer's disease and multisystem infectious disease. It is one of the major causes of nursery mortality in swine herds. Cefquinome (CEQ) is proposed for the treatment of pigs against respiratory tract infection. However, few studies have investigated the PK/PD characteristics and PK/PD cutoff of this drug against H. parasuis. RESULTS A tot...