نتایج جستجو برای: cdr2

تعداد نتایج: 253  

Journal: :The Journal of Experimental Medicine 1992
C Chen V A Roberts M B Rittenberg

We have investigated the impact of mutations on the binding functions of the phosphocholine (PC)-specific T15 antibody in the absence of antigen selection pressure. The H chain complementarity determining region 2 (CDR2) sequence of T15 antibody was saturated with point mutations by in vitro random mutagenesis. From the mutant library, 289 clones were screened by direct DNA sequencing. The poin...

Journal: :Journal of immunology 2000
Y C Zang J Hong V M Rivera J Killian J Z Zhang

T cell responses to myelin basic protein (MBP) are potentially involved in the pathogenesis of multiple sclerosis (MS). Immunization with irradiated MBP-reactive T cells (T cell vaccination) induces anti-idiotypic T cell responses that suppress circulating MBP-reactive T cells. This T cell-T cell interaction is thought to involve the recognition of TCR expressed on target T cells. The study was...

2016
Oluwaseun Ayodeji Ishola Seng Yeat Ting Yasser M Tabana Mowaffaq Adam Ahmed Muhammad Amir Yunus Rafeezul Mohamed Leslie Thian Lung Than Doblin Sandai

BACKGROUND A major characteristic of Candida biofilm cells that differentiates them from free-floating cells is their high tolerance to antifungal drugs. This high resistance is attributed to particular biofilm properties, including the accumulation of extrapolymeric substances, morphogenetic switching, and metabolic flexibility. OBJECTIVES This study evaluated the roles of metabolic processe...

Journal: :South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde 2013
James H Irlam Bongani M Mayosi Mark E Engel Thomas A Gaziano

Primary prevention of acute rheumatic fever (ARF) and rheumatic heart disease (RHD) in children depends on prompt and effective diagnosis and treatment of pharyngitis at the primary level of care. Cost-effectiveness modeling shows that the most cost-effective strategy for primary prevention in South Africa (SA) is to use a simple symptomatic clinical decision rule (CDR) to diagnose pharyngitis ...

Journal: :Acta biochimica Polonica 2015
Karolina Gołąbek Joanna Katarzyna Strzelczyk Aleksander Owczarek Piotr Cuber Anna Ślemp-Migiel Andrzej Wiczkowski

A phenomenon of increasing resistance of Candida spp. to azoles has been observed for several years now. One of the mechanisms of lack of sensitivity to azoles is associated with CDR1, CDR2, MRD1 genes (their products are active transport pumps conditioning drug efflux from pathogen's cell), and ERG11 gene (encoding lanosterol 14α-demethylase). Test material was 120 strains of Candida albicans ...

2000
Peter S. Andersen Evan A. Parke Roy A. Mariuzza David M. Kranz

Binding of the T cell receptor (TCR) to a bacterial superantigen (SAG) results in stimulation of a large population of T cells and subsequent inflammatory reactions. To define the functional contribution of TCR residues to SAG recognition, binding by 24 single-site alanine substitutions in the TCR V b domain to Staphylococcus aureus enterotoxin (SE) C3 was measured, producing an energy map of t...

Journal: :The Journal of Experimental Medicine 2000
Hywyn R.O. Churchill Peter S. Andersen Evan A. Parke Roy A. Mariuzza David M. Kranz

Binding of the T cell receptor (TCR) to a bacterial superantigen (SAG) results in stimulation of a large population of T cells and subsequent inflammatory reactions. To define the functional contribution of TCR residues to SAG recognition, binding by 24 single-site alanine substitutions in the TCR Vbeta domain to Staphylococcus aureus enterotoxin (SE) C3 was measured, producing an energy map of...

Journal: :Annals of Clinical and Translational Neurology 2020

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1984
N Takahashi T Noma T Honjo

We have cloned two rearranged heavy chain variable region (VH) genes from the IgG-producing human cell line CESS. The VH gene, which is linked to the mu chain constant region (C mu) gene, has two deletions at residues 45-62 and 82A-90, the former of which corresponds closely to the second complementarity-determining region (CDR2). These results could indicate that translocation of CDR2 occurred...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2009
Kira Rubtsova James P Scott-Browne Frances Crawford Shaodong Dai Philippa Marrack John W Kappler

We have hypothesized that in the prenegative selection TCR repertoire, many somatically generated complementary-determining region (CDR) 3 loops combine with evolutionarily selected germline Valpha/Vbeta CDR1/CDR2 loops to create highly MHC/peptide cross-reactive T cells that are subsequently deleted by negative selection. Here, we present a mutational analysis of the Vbeta CDR3 of such a cross...

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