Coordination of the cell cycle with developmental events is crucial for generation of tissues during development and their maintenance in adults. Defects in that coordination can shift the balance of cell fates with devastating clinical effects. Yet our understanding of the molecular mechanisms integrating core cell cycle regulators with developmental regulators remains in its infancy. This wor...

More recently medical chemistry research has been focused on proteins that drive and controlcell cycle progression. Among them, the cyclin dependent kinases (cdk’s) are a group ofserine/threonine kinases, which rule the transition between successive stages of the cell cycle. Theactivity of cdk’s is regulated by multiple mechanisms, including binding to cyclins, which is a broadclass of positive...

PURPOSE Climatic droplet keratopathy (CDK) is a degenerative disease of the cornea with possible involvement from matrix metalloproteinases (MMPs). Therefore, the authors investigated histologic distribution, levels, and molecular forms of MMP-2 and MMP-9, as well as tear fluid levels of MMPs and cytokines in CDK patients. They additionally examined UV-B-irradiation effect on production of gela...

Abstract Cyclin-dependent kinase 12 (CDK12) is a member of the CDK family proteins (CDK) and critical for cancer development. Years study into CDK12 have generated much information regarding intricacy its function mechanism as well inhibitors against it oncological research. However, there remains lack understanding role in carcinogenesis prevention. An exhaustive comprehension will highly stim...

To maintain genome stability during fluctuating environmental conditions, cells have adapted mechanisms to regulate cell cycle events. For unicellular organisms, such as budding yeast, this response is essential for the survival of the organism. For example, under conditions of nutrient limitation, diploid budding yeast cells enter meiosis and package the meiotic products into spores. The spore...

more recently medical chemistry research has been focused on proteins that drive and controlcell cycle progression. among them, the cyclin dependent kinases (cdk’s) are a group ofserine/threonine kinases, which rule the transition between successive stages of the cell cycle. theactivity of cdk’s is regulated by multiple mechanisms, including binding to cyclins, which is a broadclass of positive...

16 Meiotic cells undergo a single round of DNA replication followed by two rounds of 17 chromosome segregation (the meiotic divisions) to produce haploid gametes. Both DNA 18 replication and chromosome segregation are similarly regulated by CDK oscillations in mitotic 19 cells. Yet how these two events are uncoupled between the meiotic divisions is unclear. Using 20 Saccharomyces cerevisiae, we...

The mechanisms underlying peroxisome proliferator-induced hepatocarcinogenesis are unclear but are mediated by the peroxisome proliferator-activated receptor alpha (PPARalpha). To determine the role of PPARalpha in the mechanisms of hepatocarcinogenesis, the effect of Wy-14,643 on expression patterns of acyl CoA oxidase (ACO) and proteins involved in cell proliferation in the PPARalpha-null mou...

Cyclin-dependent kinases (Cdk) are essential for promoting the initiation of DNA replication, presumably by phosphorylating key regulatory proteins that are involved in triggering the G1/S transition. Human Cdc6 (HsCdc6), a protein required for initiation of DNA replication, is phosphorylated by Cdk in vitro and in vivo. Here we report that HsCdc6 with mutations at potential Cdk phosphorylation...

The dominant model for eukaryotic cell cycle control proposes that cell cycle progression is driven by a succession of CDK complexes with different substrate specificities. However, in fission yeast it has been shown that a single CDK complex generated by the fusion of the Cdc13 cyclin with the CDK protein Cdc2 can drive the mitotic cell cycle. Meiosis is a modified cell cycle programme in whic...