PURPOSE To evaluate the possible mechanisms influencing the infiltration of CD8 T lymphocytes into the tumor epithelium of advanced-stage serous ovarian cancers. EXPERIMENTAL DESIGN Immunohistochemical localization of CD8 T lymphocytes was done on a homogeneous population of 184 high-grade, advanced-stage serous ovarian cancer tissue specimens. Microarray analysis was done on microdissected t...

As a result of expression of the influenza hemagglutinin (HA) in the pancreatic islets, the repertoire of HA-specific CD8+ T lymphocytes in InsHA transgenic mice (D2 mice expressing the HA transgene under control of the rat insulin promoter) is comprised of cells that are less responsive to cognate Ag than are HA-specific CD8+ T lymphocytes from conventional mice. Previous studies of tolerance ...

AbstractBackgroundcontributes substantially to patient morbidity and mortality.In this study we investigatedthe range and distribution of T-lymphocyte. Subsets CD3helper/inducer cell,.th ), CD8: Severe immunosuppression occurs after large thermal burn and probably+ (T cells) CD4+ (T+ (T suppressor /Cytotoxic cells ,TS/C), CD3+CD4thermal injury.+/CD3+CD8+ ratio, CD19+ (B cells) and CD16+ (NK cel...

BACKGROUND T cells of intraepithelial phenotype have previously been detected in bronchoalveolar lavage (BAL) fluid in a range of lung diseases; these cells express the adhesion molecule alpha(E)beta(7) integrin, CD103, the ligand for epithelial cell E-cadherin. In subjects with asthma CD4+ lymphocytes are the predominant T cell subtype found in bronchial biopsy specimens and in BAL fluid, wher...

BACKGROUND Leishmaniasis is an important parasitic disease affecting millions worldwide. Human cutaneous leishmaniasis (CL) is endemic in Rio de Janeiro, Brazil, where is caused by Leishmania braziliensis. The adaptive immune response is accountable for the healing of CL and despite of key role of CD8+ T cells in this immune response little is known about the CD8+ T lymphocytes frequencies, apo...

Background. The problem of treatment phlegmon the maxillofacial region and neck remains one most urgent problems surgery. Aim. To determine degree influence local Low Level Laser Therapy (LLLT) on quantitative functional characteristics immunocytes humoral factors in peripheral blood lavage fluid neck. Material methods. We have examined treated 60 patients with Of these, 30 people made up group...

To examine the effects of exposure to manganese (Mn) on the cellular and humoral immune system in men, T lymphocyte subpopulations, B (CD19+) lymphocytes, natural killer (NK) cells, and serum immunoglobulins (i.e., IgG, IgA and IgM) together with total T (CD3+) lymphocytes and total lymphocytes were measured in blood samples from 21 welders mainly exposed to Mn fume with blood Mn (BMn) concentr...

The development of cellular immune responses in primary human immunodeficiency virus type-1 (HIV-1) infection is accompanied by a dramatic decrease in plasma viremia and resolution of the acute clinical syndrome. The full nature of the immunological response and its consequences on HIV pathogenesis is still largely a mystery, but significant progress has been achieved in the characterization of...

胃癌是最常见的消化道恶性肿瘤。已有研究表 明 ,中医药治疗可以增强癌症患者的免疫功能、减轻 放化疗的毒副反应、改善临床症状 , 不仅能提高远期 生存率 ,更重要的是能提高患者的生存质量 [ 1 ] 。 至精颗粒是张镜人教授研制的抗癌中药方 , 由 太子参、炒当归、灵芝草、黄精、淮山药、炒杜仲、白花 舌蛇草、蜀羊泉等中药组成。本临床研究结果显示 , 中药联合化疗组中医症状改善总有效率为68 .18% , 化疗 组为 43 .33% ; 中 药 联合 化 疗组 生存 质 量 ( Karnosfky 评分 ) 提高率 为 42 .04 %、降低 率为 9 .09 % ,化疗组生存质量提高率为 16 .67%、降低率 为 31 . 67% ; 中 药 联 合 化 疗 组 体 重 增 长 率 为 36 .36%、稳定率为 43 .18%、进展率为 20 .45% , 化 疗组体重增长率为 13...

The percentages of CD3+, CD4+ and CD8+ T lymphocytes that expressed BTLA from RA patients were all higher than those of the controls (all p < 0.05), while the percentages of CD3+, CD4+ and CD8+ T lymphocytes that expressed HVEM and LIGHT were all lower than those of the controls (all p < 0.05). The rheumatoid factor and the percentage of HVEM +CD4+ T lymphocytes showed a statistically significa...