نتایج جستجو برای: cd8 cd28

تعداد نتایج: 42691  

Journal: :Journal of immunology 2010
Yufeng Li Shujuan Liu Jessica Hernandez Luis Vence Patrick Hwu Laszlo Radvanyi

We determined how CD8(+) melanoma tumor-infiltrating lymphocytes (TILs) isolated from two distinct phases of expansion in preparation for adoptive T cell therapy respond to melanoma Ag restimulation. We found that TILs isolated after the rapid expansion protocol (REP) phase, used to generate the final patient TIL infusion product, were hyporesponsive to restimulation with MART-1 peptide-pulsed ...

2016
Hailong Liang Jing Zhao Guosheng Xing Huiyun Cai Jing Liu Wenqing Wei Xiangyang Chu

Antitumor immune response is usually inhibited by immunosuppressive tumor microenvironment. CD8+CD28T lymphocyte (Ts; or CD8+ Treg) is another regulatory T cell apart from CD4+CD25highCD127low Treg, and it has been detected infiltrating in tumor tissue of various types as well. The aim of this study is to investigate possible role of both Tregs in peripheral circulation of non small cell lung c...

Journal: :Journal of immunology 2002
Katsuhiko Fukada Yuji Sobao Hiroko Tomiyama Shinichi Oka Masafumi Takiguchi

Because the chemokine receptor CCR5 is expressed on Th1 CD4(+) cells, it is important to investigate the expression and function of this receptor on other T cells involved in Th1 immune responses, such as Ag-specific CD8(+) T cells, which to date have been only partially characterized. Therefore, we analyzed the expression and function of CCR5 on virus-specific CD8+ T cells identified by HLA cl...

Journal: :The Journal of Experimental Medicine 1993
F A Harding J P Allison

The activation requirements for the generation of CD8+ cytotoxic T cells (CTL) are poorly understood. Here we demonstrate that in the absence of exogenous help, a CD28-B7 interaction is necessary and sufficient for generation of class I major histocompatibility complex-specific CTL. Costimulation is required only during the inductive phase of the response, and not during the effector phase. Tra...

Journal: :JCI insight 2018
Danya Liu I Raul Badell Mandy L Ford

Memory T cells pose a significant problem to successful therapeutic control of unwanted immune responses during autoimmunity and transplantation, as they are differentially controlled by cosignaling receptors such as CD28 and CTLA-4. Treatment with abatacept and belatacept impede CD28 signaling by binding to CD80 and CD86, but they also have the unintended consequence of blocking the ligands fo...

Journal: :Transplant immunology 2010
P Renner F C Popp E Eggenhofer P Slowik P Piso E K Geissler H J Schlitt M H Dahlke

The immunomodulatory properties of CD8 T cells with regulatory phenotype have become evident. It remains unclear whether the immunomodulatory function of CD8(+)CD28(-) T cells requires antigen-specific TCR interaction with major histocompatibility complex class I (MHC I). We have isolated naïve CD8(+)CD28(-) T suppressor cells (Tsup) from H2-Kk Des-TCR mice that express a transgenic, MHC class ...

Journal: :Journal of immunology 2007
Hua Zhang Kristen M Snyder Megan M Suhoski Marcela V Maus Veena Kapoor Carl H June Crystal L Mackall

Artificial APCs (aAPCs) genetically modified to express selective costimulatory molecules provide a reproducible, cost-effective, and convenient method for polyclonal and Ag-specific expansion of human T cells for adoptive immunotherapy. Among the variety of aAPCs that have been studied, acellular beads expressing anti-CD3/anti-CD28 efficiently expand CD4+ cells, but not CD8+ T cells. Cell-base...

2015
Danya Liu Suzanne J. Suchard Steve G. Nadler Mandy L. Ford Stanislaw Stepkowski

Programmed T cell differentiation is critically influenced by the complement of costimulatory and coinhibitory signals transmitted during initial antigen encounter. We previously showed that selective CD28 blockade with novel domain antibodies that leave CTLA-4-mediated coinhibitory signaling intact resulted in more profound attenuation of donor-reactive T cell responses and improved graft surv...

Journal: :Blood 1998
X Z Yu P J Martin C Anasetti

Because CD28-mediated T-cell costimulation has a pivotal role in the initiation and maintenance of T-cell responses, we tested the hypothesis that CD28 is critical for the development of graft-versus-host disease (GVHD). We compared the in vivo effects of CD28(-/-) T cells transplanted from B6 donor with the CD28 gene deleted by homologous recombination with those of CD28(+/+) T cells transplan...

Journal: :Science 2017
Alice O Kamphorst Andreas Wieland Tahseen Nasti Shu Yang Ruan Zhang Daniel L Barber Bogumila T Konieczny Candace Z Daugherty Lydia Koenig Ke Yu Gabriel L Sica Arlene H Sharpe Gordon J Freeman Bruce R Blazar Laurence A Turka Taofeek K Owonikoko Rathi N Pillai Suresh S Ramalingam Koichi Araki Rafi Ahmed

Programmed cell death-1 (PD-1)-targeted therapies enhance T cell responses and show efficacy in multiple cancers, but the role of costimulatory molecules in this T cell rescue remains elusive. Here, we demonstrate that the CD28/B7 costimulatory pathway is essential for effective PD-1 therapy during chronic viral infection. Conditional gene deletion showed a cell-intrinsic requirement of CD28 fo...

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