Background: The aim of preliminary study was determined development process status of T-cell population lymphocytes in Ukrainian children after 22 years from Chernobyl accident for next feasibility study. Material and Method: 150 participants aged 6 to 16 years are included in three groups: Group I (n=65), 30 to 60 km from center accident at zone 3th, Group II (n=65) 60 to 90 km from s...

Objective(s): Regulatory T cells, including CD4+CD25+Fox3+ and CD8+CD28- cells play an important role in regulating the balance between immunity and tolerance. Since multiple sclerosis is an inflammatory autoimmune disease, regulatory T cells are considered to be involved in its pathogenesis. In this study, we investigated the circulatory numbers of the two mentioned types of regulatory T cells...

the ratio of cd4+/cd8+ has been used as a clinically index to evaluate patients' immunity. numerous researchers have studied cd4+/cd8+ ratio in pulmonary tuberculosis (ptb) patients. however, the change of cd4+/cd8+ ratio remains controversial. we present a meta-analysis of 15 case-control studies to identify the change of cd4+/cd8+ ratio in ptb patients.we assessed heterogeneity of effect esti...

- the case definition for the syndrome of idiopathic cd4+ t-hymphocytopenia (1cl) includes a heterogeneity of disorders. as yet there have been very few published reports of chiulren who meet the whojcdc criteria and it is unclear whether icl is an acquired or inherited disorder. chiulren referred to a pacdiatric immunodeficiency unit between 1991 and 1993 for investigation of immunodeficiency ...

psychological or behavioral interventions that attenuate the effects of stress may be useful in promoting immunocompetence and delaying hiv disease progression and cd4 count level. mindfulness-based stress reduction (mbsr) is a behavioral intervention that has as its foundation the practice of insight-oriented (or mindfulness) meditation. in this study, we examined the effects of mbsr upon psyc...

local inflammatory processes in the gastric mucosa are followed by extensive immune cell infiltration, resulting in chronic active gastritis characterized by a marked infiltration of t(h)1 cytokine-producing cd4+ and cd8+t-cells objective. to investigate the correlation between cd4+/cd8+ t-cells in gastric mucosa with endoscopic appearance in chronic gastritis with or without h.pylori infection...

Background. We aimed to analyze the contents of main CD4+ T-cell subsets in patients with atherosclerosis (AS) depending on age. Methods. Male coronary and/or carotid AS, who are non-smokers, and receiving statins were divided into three age groups (I—<55 y.o. (n = 23), II—55–64 42), III—≥65 46)). Leukocyte phenotyping was performed by direct immunofluorescence flow cytometry. For intracellu...

Objective(s): In this study, we aimed to investigate the effects of anti-Fas ribozyme on the apoptosis of T lymphocytes (T cells) in mice model with chronic obstructive pulmonary disease (COPD). Materials and Methods: Male 6-week-old C57BL/6 mice were used to establish the COPD model by exposure to cigarette smoke. The COPD mice were sacrificed for spleen dissection and T cell isolation. T cell...

cryptococcus neoformans is the most incriminated fungal pathogen causing meningitis in acquired immune deficiency syndrome (aids) patients, and is known to constitute a major cause of deaths in aids patients. this study aimed to determine the sero-prevalence and effect of cd4 count on seropositivity for cryptococcus neoformans antigen (crag) in antiretroviral- naïve (art-naïve) aids patients. t...