The asymmetric unit of the title compound, (C(7)H(18)N(2)O)(2)[Cd(2)Cl(8)], comprises one 4-(2-hy-droxy-eth-yl)-2-methyl-piperazine-1,4-diium dication and a half [Cd(2)Cl(8)](4-) anion. The two Cd atoms are each coordinated by two bridging Cl atoms and three terminal Cl atoms and the [Cd(2)Cl(8)](4-) anion is located on an inversion centre. The crystal structure consists of N-H⋯Cl hydrogen-bond...

BACKGROUND Cadmium (Cd) is classified as a human carcinogen probably associated with epigenetic changes. DNA methylation is one of epigenetic mechanisms by which cells control gene expression. Therefore, the present study genome-widely screened the methylation-altered genes in the liver of rats previously exposed to low-dose Cd. METHODOLOGY PRINCIPAL FINDINGS Rats were exposed to Cd at 20 nmo...

Caspase-8, the essential initiator caspase, is believed to play a pivotal role in death receptor-mediated apoptotic pathway. It also participates in mitochondria-mediated apoptosis via cleavage of proapoptotic Bid in mammals. However, its role in fish remains elusive in Cadmium-induced apoptotic pathway. In this study, we isolated the caspase-8 gene from common carp, one of the most important i...

BACKGROUND Exposure to traffic-related air pollutants, including polycyclic aromatic hydrocarbons (PAH) and heavy metals, has been associated with the etiology and prognosis of many illnesses. However, the specific causal agents and underlying mechanisms for different health outcomes remain unclear. The aims of this study were to assess the relations between urinary biomarkers of exposure to PA...

The distribution and chemical behavior of Cd(2+) in tissues and its chemical form in xylem water of soybean plants (cv. Williams) were investigated. Following root absorption, Cd is strongly retained by roots, with only 2% of the accumulated Cd being transported to leaves; as much as 8% was transported to seeds during seed filling. In vivo xylem exudates contained two anionic Cd complexes in ad...

Biancheri P et al. Abnormal thymic stromal lymphopoietin expression in the duodenal mucosa of patients with coeliac disease. Gut 2015;0:1-11 The expression of epithelial-derived thymic stromal lymphopoietin (TSLP), a key cytokine modulator of gut immune tolerance, may be dysregulated in coeliac disease (CD). This study investigated TSLP expression along the clinical spectrum of CD and evaluated...

The objective of the present study was to compare the chemical and sensory properties of regular cream cheese (control) and cholesterol-reduced cream cheese manufactured using crosslinked β-cyclodextrin (β-CD) or powdered β-CD. Crosslinked β-CD was made using adipic acid. The composition of cream cheese treated by the crosslinked β-CD was similar to the regular cream cheese. Approximately 91% o...

BACKGROUND Diagnosing peanut allergy properly is important and can be achieved by combining clinical history with various diagnostic methods such as IgE-antibody (IgE-ab) measurements, skin-prick test, basophil allergen threshold sensitivity (CD-sens) and food challenge. We aimed to evaluate CD-sens to peanut, Ara h 8 and Gly m 4 in relation to an oral peanut challenge in children IgE-sensitize...