نتایج جستجو برای: cationic liposomes

تعداد نتایج: 31719  

2011
Wei Zhao Song Zhuang Xian-Rong Qi

Neutral liposomes (NLP) exhibit preferential localization in solid tumors based on the enhanced permeation and retention (EPR) effect. Cationic liposomes (CLP) have a propensity for localizing in newly formed tumor vessels and they have a potentially enhanced antitumor effect. However, an increased amount of cationic lipids in liposomes also induces aggregation through electrostatic interaction...

Journal: :Anticancer research 2016
Xiaoyuan Ma Y I Wu Xuewei Yang Shuang Yang Yuhuan Li Yushen Huang Robert J Lee Tian Bai Yungang Luo

AIM We screened nine 1,2-dihydro-quinolines using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) cytotoxicity assay in HepG2 and SMMC cells and identified ethyl-2-cyano-2-(2- (methoxycarbonyl)allyl)quinoline-1(2H)-carboxylate (compound 5) as a potential anticancer agent. In order to further develop its anticancer therapeutic potential, we incorporated this agent into cat...

Journal: :Chemical communications 2007
Richard G Uhl Amalia Stevenson Vladimir Sidorov

Hyperpolarization of cationic liposomes improves their stability in the presence of human serum albumin.

Journal: :Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 2008
Hirofumi Tani Mizuyo Notani Tamio Kamidate

Firefly bioluminescence (BL) was greatly affected by cationic surfactants coexisting with liposomes containing phosphatidylcholine and cholesterol. In this study, the effects of the type and concentration of cationic surfactants on BL were studied in the presence of the liposomes. Three types of cationic surfactant: benzalkonium chloride (BAC), n-dodecyltrimethylammonium bromide (DTAB), and ben...

2003
Anas El-Aneed

Anas El-Aneed is a doctoral student in biochemistry at the School of Pharmacy at Memorial University of Newfoundland, 300 Prince Philip Dr., St. John’s, NL, A1B 3V6 Canada, tel. 709.737.4331, fax 709.777.7044, anas@pharm.mun.ca. ationic liposomes are widely used to transfer genetic materials into specific cells. A good liposomal formulation for gene therapy should encapsulate and protect the nu...

2006
Shuji KITAGAWA

been shown to form bilayer vesicles (cationic liposomes) and have been applied to gene delivery. Cationic vesicles designed for that purpose are generally intrinsically unstable. Although application of cationic liposomes has also been anticipated for the delivery of drugs, peptides, vitamins and lipids and other biologically active compounds to biological cells and tissues, liposomes used for ...

Journal: :Biological & pharmaceutical bulletin 2011
Naoyuki Toriyabe Yasuhiro Hayashi Mamoru Hyodo Hideyoshi Harashima

Hyaluronic acid (HA) is a naturally-occurring ligand that can be useful for targeting liver endothelial cells. We describe herein the development of a new HA-lipid conjugate for the efficient delivery of liposomes to liver endothelial cells. When free HA coated cationic liposomes were injected into mice, their accumulation in the liver was significantly decreased depending on the content of fre...

2013
Mostafa Saffari Farshad H. Shirazi Mohammad Ali Oghabian Hamid Reza Moghimi

The current methods for treatment of cancers are inadequate and more specific methods such as gene therapy are in progress. Among different vehicles, cationic liposomes are frequently used for delivery of genetic material. This investigation aims to prepare and optimize DOTAP cationic liposomes containing an antisense oligonuclotide (AsODN) against protein kinase C alpha in non-small cells lung...

Journal: :Angewandte Chemie 2021

A lipid named DCPA was synthesized under microwave-assisted heating. possesses a pyridine betaine, hydrophilic group that can be complexed with water through hydrogen bonding (DCPA-H2O). DCPA-H2O liposomes became protonated relatively fast already at pH<6.8, due to the high HOMO binding energy of DCPA-H2O. In murine models, had longer blood circulation times than natural DPPC or cationic DCPM l...

2016
Yoshiyuki Hattori

For systemic injection of cationic liposome/plasmid DNA (pDNA) complexes (cationic lipoplexes), polyethylene glycol (PEG)-modification (PEGylation) of lipoplexes can enhance their systemic stability. In this study, we examined whether intravenous injection of PEGylated cationic lipoplexes into tumor-bearing mice could deliver pDNA into tumor tissues and induce transgene expression. PEGylation o...

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