Candida albicans is the most frequently encountered fungal pathogen in humans, capable of causing mucocutaneous and systemic infections in immunocompromised individuals. C. albicans virulence is influenced by multiple factors. Importantly, iron acquisition and avoidance of the immune oxidative burst are two critical barriers for survival in the host. Prior studies using whole genome microarray ...

Title: Ketogenic Diets as an Adjuvant Therapy in Glioblastoma (The KEATING Trial): Study Protocol for a Randomised Pilot Study Authors: Kirsty Martin-McGill ([email protected]) Anthony Marson ([email protected]) Catrin Tudur Smith ([email protected]) Michael Jenkinson ([email protected]) Version: 2 Date: 18 Aug 2017 Author’s response to reviews: Dear Dr Lehana ...

The intestinal Ca(2+) transport protein CaT1 has recently been shown to have the biophysical characteristics of the Ca(2+)-release activated Ca(2+) channel that refills internal Ca(2+) stores following agonist-elicited release. This finding highlights a hitherto unrecognized link between epithelial Ca(2+) transport and Ca(2+) signalling.

Catalase plays a key role as an antioxidant, protecting aerobic organisms from the toxic effects of hydrogen peroxide, and in some cases has been postulated to be a virulence factor. To help elucidate the function of catalase in Candida albicans, a single C. albicans-derived catalase gene, designated CAT1, was isolated and cloned. Degenerate PCR primers based on highly conserved areas of other ...

We previously identified several members of the SLC7 transporter family as potential system c transporters based on immunofluorescence data and, for functionally characterized members, on cysteamine-cysteine competition experiments. CAT2A, CAT2B, an orphan CAT-like protein named SLC7A14 and, to a lesser extent, CAT1 appeared as good system c candidates. However, it is still unknown which of the...

The CSRE (carbon source-responsive element) is a sequence motif responsible for the transcriptional activation of gluconeogenic structural genes in Saccharomyces cerevisiae. We have isolated a regulatory gene, DIL1 (derepression of isocitrate lyase, = CAT8), which is specifically required for derepression of CSRE-dependent genes. Expression of CAT8 is carbon source regulated and requires a func...