The Castleman disease (CD) is a rare disease of unknown etiology, characterized histologically by angiofollicular lymphoid hyperplasia. It comes in two forms, unicentric and multicentric. We report a case of Castleman disease in a 58 year old man, who had consulted for chronic cervical lymphadenopathy. This case was a multicenteric and rapidly fatal despite aggressive treatment with corticoster...

Jae Hyun Ryu, Jung Woo Oh, Kwang Ho Kim, Joon Il Choi, Kyoung Ho Ryu, Yoon Jung Kim, Tae Young Jung From the Departments of Urology and Pathology, Seoul Veterans Hospital, Seoul, Korea Castleman disease, or angiofollicular lymph node hyperplasia, is a fairly rare benign tumor of lymphoid origin. Most cases tend to present as a mediastinal mass. We report a 58-year-old man with Castleman disease...

BACKGROUND Castleman disease is an uncommon lymphoproliferative disorder characterized as either unicentric or multicentric. Unicentric Castleman disease (UCD) is localized and carries an excellent prognosis, whereas multicentric Castleman disease (MCD) is a systemic disease occurring most commonly in the setting of HIV infection and is associated with human herpesvirus 8. MCD has been associat...

castleman disease (cd) is a rare, lymphoproliferative disorder of uncertain etiology. we are reporting on two cases of castleman disease. both patients were female. this disease can be found wherever lymph nodes are present. we have reported two unusual cases of castleman disease. a 29- year old woman was referred for evaluation because of a cervical lymph node, weight loss and night sweats. th...

BACKGROUND Castleman-Kojima disease (TAFRO Syndrome) is characterized by Thrombocytopenia, Anasarca, myeloFibrosis, Renal dysfunction, Organomegaly, multiple lymphadenopathy and histopathology pattern of atypical Castleman's disease (CD). Only few cases of this recently identified unique variant of Multicentric CD (MCD) are described in literature, all Japanese. It therefore poses serious diagn...

POEMS syndrome is a rare multisystem disorder that clinically manifests as paraneoplastic and monoclonal plasma cell dyscrasia. Its acronym derived from its principal characteristics: polyneuropathy, organomegaly, endocrinopathy, M proteins, skin changes. Here, case of was reported also having features Castleman disease. A 43-year-old man admitted with weakness all four limbs, tingling, heavine...

Castleman disease is a syndrome with significant clinico-pathological overlap between malignancy, autoimmune causes and infectious etiologies. It spectrum can vary in extent from unicentric to multicentric generalized lymphadenopathy, organ involvement, constitutional symptoms cytopenias, severity non-severe severe TAFRO symptoms. Idiopathic (iMCD) diagnosis of exclusion after multiple as per d...

Macrophage Activating Syndrome (MAS) is a life-threatening disease seen in autoimmune diseases including lupus erythematosus, rheumatoid arthritis, Still's disease, polyarteritis nodosa. It is characterized by fever, pancytopenia, liver failure, coagulopathy, and neurologic symptoms and high serum ferritin. A 27 yr. old female patient was admitted in shahid Mostafa Khomeini Hospital (Tehran-Ira...

Castleman disease is a relatively rare disorder of lymphoid tissue that involves the gastrointestinal tract in a variety of clinical and pathologic manifestations. A submucosal location has never been described in the medical literature. We report a case of esophageal Castleman disease involving the submucosal layer in a 62-year-old man, which was confirmed on pathology. Esophagography and CT d...

This case suggests that POEMS syndrome does present with a constellation of signs and symptoms may lead clinician to multitude other possible diagnoses. Diagnosis is often difficult delayed. A good history physical examination as well careful review all workups are paramount in establishing this particular diagnosis. The major criteria diagnostic for the polyradiculoneuropathy, clonal plasma di...