BACKGROUND The immobilization-induced tibialis anterior (TA) muscle atrophy worsens after cast removal and is associated with altered extracellular matrix (ECM) composition. The secreted protein acidic and rich in cysteine (Sparc) is an ECM component involved in Akt activation and in β-catenin stabilization, which controls protein turnover and induces muscle regulatory factors (MRFs), respectiv...

Postoperative early kinesitherapy has been advocated as an optimal method for treating Achilles tendon rupture. However, an insight into the rationale of how early kinesitherapy contributes to healing of Achilles tendon remains to be achieved, and research in the area of proteomic analysis of Achilles tendon has so far been lacking. Forty-two rabbits were randomized into control group, immobili...

Nondisplaced fractures of the scaphoid heal with cast immobilization in most cases, but operative treatment is being offered with greater frequency to active patients as an approach to reduce the period of cast immobilization. Computed tomography is more useful for evaluating displacement than standard radiography. Displaced fractures are at greater risk for nonunion and malunion-both of which ...

The objective was to determine if strength training the free limb during a 3-wk period of unilateral immobilization attenuates strength loss in the immobilized limb through cross-education. Thirty right-handed participants were assigned to three groups. One group (n = 10) wore a cast and trained the free arm (Cast-Train). A second group (n = 10) wore a cast and did not train (Cast). A third gro...

BACKGROUND Distal radius fractures (DRFs) are the second most common fractures, after hip fractures, seen in clinical practice. The high incidence of low-energy trauma DRFs in elderly patients raises questions about the best treatment method in terms of function, pain, and quality of life. Although the majority of these fractures are treated non-operatively with cast immobilization, valid scien...

OBJECTIVE To investigate the possible effects of regular swimming exercise on bone mineral density (BMD) compared with free activity after cast immobilization of rats. METHODS We carried out the study from April 2005 to June 2005 at the Department of Sports Medicine, Medical School of Suleyman Demirel University, Isparta, Turkey. The study included a total of 24 female Wistar rats. The rats w...

OBJECTIVE Stretching exercise is known to induce muscle hypertrophy and is implicated in the modulation of muscle fiber behavior. We aim to determine whether stretching exercise is protective against reloading-induced muscle damage in immobilized rat soleus muscle. METHODS Rat hindlimbs in 54 eight-week-old male Wistar rats were immobilized by cast for 4 weeks, followed by reloading alone thr...

UNLABELLED The study of complex regional pain syndrome (CRPS) in humans is complicated by inhomogeneities in available study cohorts. We hoped to characterize early CRPS-like features in patients undergoing hand surgery. Forty-three patients were recruited from a hand surgery clinic that had elective surgeries followed by cast immobilization. On the day of cast removal, patients were assessed f...

The effect of tamoxifen citrate on bone mass in immobilization osteoporosis was studied in 10 dogs.Osteoporosis was induced by fiberglass cast immobilization of the right hind-limb for 28 days, while the lefthind-limb served as a non-immobilized control. Five dogs received tamoxifen citrate (1.5 mg/kg per os) once daily for 28 days; five dogs received no treatment. All dogs were euthanized on d...

Objective: While surgical treatment is the most accepted method for displaced supracondylar humerus fractures in children, there little data about immobilization after surgery. The aim of study to determine whether any difference preventing loss reduction between long-arm cast and splint following pediatric fracture Patients Methods: We conducted a retrospective analysis patients with treated o...