BACKGROUND It was unclear whether chronic endometrial ischemia contributed to the pathogenesis of thin endometrium and was associated with decreased endometrial stem/progenitor cell. Thus, we explored the role of chronic endometrial ischemia in the pathogenesis of thin endometrium and its effect on endometrial stem/progenitor cells apoptosis. MATERIAL/METHODS In vitro, endometrial side popula...

Abstract Background Rotavirus (RV) is a major pathogen that causes severe gastroenteritis in infants and young animals. Endoplasmic reticulum (ER) stress subsequent apoptosis play pivotal role virus infection. However, the protective mechanisms of intestinal damage caused by RV are poorly defined, especially molecular pathways related to enterocytes apoptosis. Thus, aim this study was investiga...

Objective: The study was designed to evaluate the role of Human cytomegalovirus (HCMV) infection on homebox (HOX) gene expression and the effects of overexpression of HOX genes on proliferation and apoptosis of vascular smooth muscle cells (VSMCs). Methods: Viral infection was verified by observation of cytopathic effects through inverted microscopy, viral particles by electron microscopy and H...

endoplasmic reticulum (er) stress provides abnormalities in insulin action, inflammatory responses, lipoprotein b100 degradation and hepatic lipogenesis. excess accumulation of triglyceride in hepatocytes may also lead to disorders such as non-alcoholic fatty liver disease (nafld) and nonalcoholic steatohepatitis (nash). opioid peptides are involved in triglyceride and cholesterol dysregulat...

Mesial temporal lobe epilepsy (MTLE) is a severe neurological condition of unknown pathogenesis for which several animal models have been developed. To obtain a better understanding of the underlying molecular mechanisms and identify potential biomarkers of lesion progression, we used a rat kainic acid (KA) treatment model of MTLE coupled with global gene expression analysis to examine temporal...

The transcription factor, Zinc finger of the cerebellum (ZIC1), plays a crucial role in vertebrate development. Recently, ZIC1 has also been found to participate in the progression of human cancers, including medulloblastomas, endometrial cancers, and mesenchymal neoplasms. However, the function of ZIC1 in colon cancer progression has not been defined. In this study, we demonstrate ZIC1 to be s...