objective(s):  coronary artery disease (cad) which may lead to myocardial infarction (mi) is a complex one. great effort has been devoted to identification of genes that increase susceptibility to cad or provide protection. a 21-bp deletion in the mef2a gene, which encodes a member of the myocyte enhancer factor 2 family of transcription factors, has been reported in patients of a single pedigr...

Usually the existence of influential observations is complicated by the presence of collinearity in linear measurement error models. However no method of influence measure available for the possible effect's that collinearity can have on the influence of an observation in such models. In this paper, a new type of ridge estimator based corrected likelihood function (REC) for linear measurement e...

Introduction: Gaseous air pollutants can cause oxidative stress, which can lead to lung damage by inducing inflammation. Polymorphisms in the glutathione S-transferase (GST) gene are involved in the pathogenesis of many diseases, including lung disease. Two glutathione S-transferase Mu 1 (GSTM1) and glutathione S-transferase theta 1 (GSTT1) genes belong to this family, in which deletions occur ...

 Background: Spinal muscular atrophy (SMA) is the second most common lethal autosomal recessive disease. It is a neuromuscular disorder caused by degenerative of lower motor neurons and occasionally bulbar neurons leading to progressive limb paralysis and muscular atrophy. The SMN1 gene is recognized as a SMA causing gene while NAIP has been characterized as a modifying factor for the clinical ...

The number-theoretic code is a class of codes defined by single or multiple congruences. These are mainly used for correcting insertion and deletion errors, asymmetric errors. This paper presents formula generalization the complete weight enumerator codes. allows us to derive enumerators cardinalities As special case, this provides Hamming non-binary Tenengolts’ codes, deletion. Moreover, we sh...

Based on the Q-function, the conditional expectation of the logarithm of the jointlikelihood between responses and random effects, we propose a case-deletion approach to identify influential subjects and influential observations in linear mixed models. The models considered here are very broad in the sense that any covariance structures can be specified in the covariance matrices of the random ...

The effectiveness and efficiency of case-based reasoning (CBR) systems depend largely on the success of case-based retrieval. The case-base maintenance (CBM) issues become imperative and important especially for modern societies. This paper proposes a new competence model and a new maintenance procedure for the proposed competence model. Based on the proposed competence maintenance procedure, f...

duchenne muscular dystrophy (dmd) and the milder allelic becker muscular dystrophy (bmd) are x-linked disorders. both dmd & bmd result from heterogenous mutation in the dystrophin gene and in about 65% of the cases one or more exons of the gene are deleted or duplicated. one third of cases arise from new mutation and the rest are familial. to analyze the prevalence of deletion in iranian patien...

in financial distress studies selection of variable is commonly basedon the success of variables in variable sets employed in earlierbankruptcy studies, suggestions in the literature or an accompanyingdata reduction in a large set of variables. if seemingly different variablesets exhibit a strong relationship then heterogeneous variable setscapture common information. canonical correlation anal...