We present a novel method for fluorescence-based indirect detection of analytes and demonstrate its use for label-free detection of chemical toxins in a hand-held device. We fluorescently label a mixture of low-concentration carrier ampholytes and introduce it into an isotachophoresis (ITP) separation. The carrier ampholytes provide a large number of fluorescent species with a wide range of clo...

background: indirect genetic diagnosis using polymorphic dna markers can detect carriers of hemophilia a. this technique is preferable in developing countries because of its simplicity and cost effectiveness compared to direct mutation analysis. in the present study, we examined usefulness of intragenic marker bcl i restriction fragment length polymorphism (rflp) at intron 18, for carrier detec...

Batten disease, or the juvenile form of neuronal ceroid lipofuscinosis, is an autosomal recessive neurodegenerative disorder manifesting with progressive blindness, seizures, and dementia, leading to an early death. The CLN3 locus which is involved in Batten disease had been localized to chromosome 16p11.2. Linkage disequilibrium has been observed between CLN3 and polymorphic microsatellite mar...

We report a novel real-time homodyne coherent receiver based on a DPSK optical-electrical-optical (OEO) regenerator used to extract a carrier from carrier-less phase modulated signals based on feed-forward based modulation stripping. The performance of this non-DSP based coherent receiver was evaluated for 10.66 Gbit/s BPSK signals. Self-homodyne coherent detection and homodyne detection with a...

Frequency selectivity in amplitude modulated sound have been reported in terms of modulation threshold level for amplitude-modulation detection, where a pink or white noise carrier was modulated with a sinusoid and band-limited white noise, which showed similar band-pass type masking characteristics. Such previous studies treated band limited white noise carriers. In this paper, an amplitude-mo...

This paper introduces a CMOS-microfluidics integration scheme for electrochemical microsystems. A CMOS chip was embedded into a micro-machined silicon carrier. By leveling the CMOS chip and carrier surface to within 100 nm, an expanded obstacle-free surface suitable for photolithography was achieved. Thin film metal planar interconnects were microfabricated to bridge CMOS pads to the perimeter ...

We propose a novel turbo detection scheme based on the factor graph serial-schedule belief propagation equalization algorithm with low complexity for single-carrier faster-than-Nyquist (FTN) and multicarrier FTN signaling. In this work, the additive white Gaussian noise channel and multi-path fading channels are both considered. The iterative factor graph-based equalization algorithm can deal w...