نتایج جستجو برای: cardiosphere derived cells
تعداد نتایج: 1746389 فیلتر نتایج به سال:
Controversy surrounds the identity, origin, and physiologic role of endogenous cardiomyocyte progenitors in adult mammals. Using an inducible genetic labeling approach to identify small non-myocyte cells expressing cardiac markers, we find that activated endogenous cardioblasts are rarely evident in the normal adult mouse heart. However, myocardial infarction results in significant cardioblast ...
The regenerative potential of cardiosphere-derived cells (CDCs) for ischaemic heart disease has been demonstrated in mice, rats, pigs and a recently completed clinical trial. The regenerative potential of CDCs from dog hearts has yet to be tested. Here, we show that canine CDCs can be produced from adult dog hearts. These cells display similar phenotypes in comparison to previously studied CDCs...
Several laboratories have shown that collection of adult cardiac stem cells can be grown directly from myocardial tissue [1–7]. Expanded cells are multipotent and clonogenic [3–5]. Spherical aggregates of cells grown from heart biopsies, termed cardiospheres, self-assemble in suspension culture and are enriched in stemness [1, 6, 7]. Andersen et al., in work on neonatal murine heart tissue, use...
Oxygen, the most important cellular nutrition, is delivered through a pulsatile blood flow in vertebrates to the tissues and cells in vivo, wherein the oxygen concentration, its availability gradient between systolic and diastolic phase of cardiac activity differ between organs. In the in vitro conditions, manipulation of oxygen availability to the cells under culture have yielded varying behav...
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