Background Clinical and epidemiological data have identified a cardiorenal syndrome (CRS), in which heart and/or kidney failure accelerates dysfunction in the other organ. New therapeutics are needed to target the mechanisms that cause CRS and treat the whole patient. The aims of this study were to 1) assess in vivo cardiorenal metabolism using hyperpolarized C MR spectroscopy (MRS) in experime...

Background: It is well established that a large number of hospitalized patients present various degrees of heart and kidney dysfunction; primary disease of the heart or kidney often involves dysfunction or injury to the other. Summary: Based on above-cited organ cross-talk, the term cardiorenal syndrome (CRS) was proposed. Although CRS was usually referred to as abruption of kidney function fol...

Currently, we are experiencing an epidemic of cardiorenal disease characterized by increasing rates of obesity, hypertension, the metabolic syndrome, type 2 diabetes, and kidney disease. Whereas excessive caloric intake and physical inactivity are likely important factors driving the obesity epidemic, it is important to consider additional mechanisms. We revisit an old hypothesis that sugar, pa...

Cardiorenal metabolic syndrome is a group of interactive conditions affecting cardiovascular, renal and systems. Treatment for this multidimensional complex, partly as result the current lack definition inclusion exclusion criteria. Symptoms can fluctuate follow nonconforming pattern, treatment dependent on severity underlying involved. A multidisciplinary service model integrate care patients ...

Background: It is well established that a large number of hospitalized patients present various degrees of heart and kidney dysfunction; primary disease of the heart or kidney often involves dysfunction or injury to the other. Summary: Based on above-cited organ cross-talk, the term cardiorenal syndrome (CRS) was proposed. Although CRS was usually referred to as abruption of kidney function fol...

The association between cardiac and renal disease has been an area of growing interest in recent years. The interactions between these organs play an important role in control of blood pressure, renal sodium and water excretion, arterial perfusion and tissue oxygenation, and, most importantly, extracellular fluid balance, including intravascular volume. It is therefore not surprising that, when...

Introduction One hundred years ago, in November of 1913, Thomas Lewis from University College Hospital, London, delivered a lecture entitled “Paroxysmal Dyspnoea in Cardio–Renal Patients,” in which he provided his clinical observations on a number of patients with dyspnea related to advanced heart and kidney disease, referred to as cardiac and uraemic asthma respectively, and expounded his theo...

The term 'cardiorenal syndrome' (CRS) has increasingly been used in recent years without a constant meaning and a well-accepted definition. To include the vast array of interrelated derangements, and to stress the bidirectional nature of the heart-kidney interactions, the classification of the CRS today includes 5 subtypes whose etymology reflects the primary and secondary pathology, the time f...

Cardiorenal syndrome (CRS) is a complex spiral of vascular disease entity, in which affliction of one organ (kidney) may adversely impact the functioning of the other (heart). Recent consensus conference has clearly defined its various types and pathophysiology. Improved survival, cardiovascular risk factors (diabetes, hypertension, dyslipidemia), diagnostic and therapeutic intervention [contra...