The fact that a low level of high-density lipoprotein (HDL) cholesterol is highly predictive of future cardiovascular events has been established in population studies beyond all reasonable doubt. Furthermore, the evidence is overwhelming that the relationship is one of cause and effect rather than an epiphenomenon, with numerous studies in animals demonstrating that HDL-raising interventions t...

Exercise training has been shown to reduce many risk factors related to cardiovascular disease, including high blood pressure, high cholesterol, obesity, and insulin resistance. More importantly, exercise training has been consistently shown to confer sustainable protection against myocardial infarction in animal models and has been associated with improved survival following a heart attack in ...

Tea is rich in polyphenolic catechins which are beneficial to health. There have been evidences suggesting that habitual tea consumption may reduce the risk of cardiovascular disease (CVD). Intake of tea or catechins isolated from tea was shown to inhibit the development of CVD in population studies and in animal models. Many possible pathways and mechanisms were investigated. There have been e...

objective: crocinisa saffron constituent with a potent anti-oxidant activity. the present study investigated the effects of crocin and insulin treatments (alone or in combination) on cardiac function and pathology in diabetic rats. materials and methods: diabetes was induced by intraperitoneal (i.p.) injection of streptozotocin (stz, 50 mg/kg). thereafter, crocin (5, 10 and 20 mg/kg, i.p.), sub...

Routine exercise is widely recognized as cardioprotective. Exercise induces a variety of effects within the cardiovasculature, including decreased mitochondrial damage and improved aerobic capacity. It has been generally thought that the transient increase in oxidative stress associated with exercise initiates cardioprotective processes. Somewhat paradoxically, increased oxidative stress associ...

Previous work described ATP-sensitive K(+) channel (K(ATP)) openers (e.g., BMS-180448), which retain the cardioprotective activity of agents such as cromakalim while being significantly less potent as vasodilators. In this study, we describe the pharmacologic profile of BMS-191095, which is devoid of peripheral vasodilating activity while retaining glyburide-reversible cardioprotective activity...

1 Acute Rosiglitazone Treatment is Cardioprotective against Ischemia/Reperfusion Injury by 1 Modulating AMPK, Akt, and JNK Signaling in Non-diabetic Mice 2 3 4 Alex Morrison, Xiaoyan Yan, Chao Tong, Ji Li 5 6 Department of Pharmacology and Toxicology, School of Medicine and Biomedical Sciences, 7 University at Buffalo-SUNY, Buffalo, NY 8 9 10 11 Running title: Cardioprotective effects of acute ...