BACKGROUND AND OBJECTIVE Hearing loss caused by congenital cytomegalovirus (cCMV) infection was first observed in 1964. Today cCMV is the most common cause of nonhereditary sensorineural hearing loss in childhood. Our objective was to provide an overview of the prevalence of cCMV-related hearing loss, to better define the nature of cCMV-associated hearing loss, and to investigate the importance...

In this report, we study the class of Cardinality Constrained Quadratic Programs (CCQP), problems with (not necessarily convex) quadratic objective and cardinality constraints. Many practical problems of importance can be formulated as CCQPs. Examples include sparse principal component analysis [1], [2], cardinality constrained mean-variance portfolio selection problem [3]–[5], subset selection...

Williams Syndrome (WS) is marked by a relative strength in verbal cognition coupled with a serious impairment in non-verbal cognition. A strong deficit in numerical cognition has been anecdotally reported in this disorder; however, its nature has not been systematically investigated. Here, we tested 14 children with WS (mean age=7 years 2 months), 14 typically developing controls individually m...

The Markowitz mean-variance portfolio selection is widely acclaimed as a very important investment strategy. A popular option to solve the static (MVPS) problem based on use of quadratic programming (QP) methods. On other hand, under transaction costs (PSTC) usually approached with nonlinear (NLP) In this article, we define and study time-varying cardinality constraint (TV-MVPSTC-CC) (TVNLP) pr...

Given a combinatorial optimization problem and a subset N of natural numbers, we obtain a cardinality constrained version of this problem by permitting only those feasible solutions whose cardinalities are elements of N . In this paper we briefly touch on questions that addresses common grounds and differences of the complexity of a combinatorial optimization problem and its cardinality constra...

BACKGROUND & METHODS Within the last decade Virus-Like Particles (VLPs) have increasingly received attention from scientists for their use as a carrier of (peptide) molecules or as scaffold to present epitopes for use in subunit vaccines. To test the feasibility of Cowpea chlorotic mottle virus (CCMV) particles as a scaffold for epitope presentation and identify sites for epitope fusion or inse...

Abstract When solving large-scale cardinality-constrained Markowitz mean–variance portfolio investment problems, exact solvers may be unable to derive some efficient portfolios, even within a reasonable time limit. In such cases, information on the distance from best feasible solution, found before optimization process has stopped, true solution is unavailable. this article, I demonstrate how p...

BACKGROUND AND OBJECTIVE: Hearing loss caused by congenital cytomegalovirus (cCMV) infection was first observed in 1964. Today cCMV is the most common cause of nonhereditary sensorineural hearing loss in childhood. Our objective was to provide an overview of the prevalence of cCMV-related hearing loss, to better define the nature of cCMV-associated hearing loss, and to investigate the importanc...