نتایج جستجو برای: cardiac conduction system disease
تعداد نتایج: 3736785 فیلتر نتایج به سال:
The cardiac conduction system comprises a specialized tract of electrically coupled cardiomyocytes responsible for impulse propagation through the heart. Abnormalities in cardiac conduction are responsible for numerous forms of cardiac arrhythmias, but relatively little is known about the gene regulatory mechanisms that control the formation of the conduction system. We demonstrate that a dista...
Background and Aim: Smoking stimulates adrenergic depletion in circulation and, theoretically, it can increase incidence and prevalence of cardiac conduction defects. In this study we wanted to know if smoking affected cardiac conduction defects in patients with acute inferior myocardial infarction (MI). Materials and Methods: In this cross- sectional study, 40 smokers and 40 non – smokers wit...
RATIONALE Nkx2.5 is one of the most widely studied cardiac-specific transcription factors, conserved from flies to man, with multiple essential roles in both the developing and adult heart. Specific dominant mutations in NKX2.5 have been identified in adult congenital heart disease patients presenting with conduction system anomalies and recent genome-wide association studies implicate the NKX2...
Background: Mutations in the gene encoding the nuclear membrane protein lamin A/C have been associated with at least 7 distinct diseases including dilated cardiomyopathy with conduction system disease, autosomal dominant Emery Dreifuss Muscular Dystrophy, limb girdle muscular dystrophy, Charcot Marie Tooth, Mandibuloacral dysplasia, lipodystrophy and progeria. Methods: We used mutation detectio...
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