INTRODUCTION Critical illness leads to increased endogenous production of carbon monoxide (CO) due to the induction of the stress-response enzyme, heme oxygenase-1 (HO-1). There is evidence for the cytoprotective and anti-inflammatory effects of CO based on animal studies. In critically ill patients after cardiothoracic surgery, low minimum and high maximum carboxyhemoglobin (COHb) levels were ...

STUDY OBJECTIVES There are large reported differences for the carboxyhemoglobin (COHb) half-life (COHb t(1/2)) in humans breathing 100% atmospheric O(2) following CO inhalation in tightly controlled experiments compared to the COHb t(1/2) observed in clinical CO poisoning (range, 36 to 131 min, respectively). Other reports have suggested that the COHb t(1/2) may be affected by gender difference...

Aim For patients with inhalation injury, the indications for early intubation are diverse. The purpose of this study was to identify the most reliable symptoms, physical findings, and medical examinations with which to determine the indications for early intubation in patients with inhalation injury. Methods We retrospectively collected patient data from medical records. Collected data includ...

BACKGROUND Carbon monoxide (CO) was previously only considered as a highly toxic pollutant since it binds to hemoglobin with high affinity. Recently, however, it has been recognized as a signaling molecule with regulatory roles in many physiological and pathophysiological processes within the cardiovascular system. The aim of this study was to clarify the behavior of CO in patients with acute c...

A sensitive gas chromatographic method for blood CO determination was used to analyze samples of reduced and oxygenated blood having identical low CO content. Oxygenated blood always released more CO than did the reduced samples when neutral ferricyanide was used as oxidant. Several reagents for CO release from blood were applied to both oxygenated and reduced samples. CO release by K3Fe(CN)6 f...

Low concentrations of endogenous carbon monoxide (CO), generated primarily through degradation of heme from heme-proteins, have been shown to maintain physiological function of organs and to exert cytoprotective effects. However, high concentrations of carboxyhemoglobin (COHb), formed by CO binding to hemoglobin, potentially prevent adequate O2 delivery to tissues by lowering arterial O2 conten...

A new method, combining fully-automated headspace gas chromatography with methaniser and flame ionisation detector (FID) is introduced to determine carboxyhemoglobin (COHb) in postmortem blood samples. This highly automated procedure utilises a robot-like autosampler for reproducible mixing and thermostating (30 min at 50°C) during carbon monoxide (CO) liberation of COHb. Apart from transferrin...

T HE RATIO OF CARBON MONOXIDE ( CO) to oxygen bound by hemoglobin A is 217 times greater than the ratio of these gas tensions in the equilibrium medium.’ This report shows that hemoglobin F has less preferential binding of CO over 02 than hemoglobin A. Because of this difference between adult and fetal hemoglobin the diffusion gradient for CO across the placenta can not be equated with the diff...

Being the most common cause of death from poisoning worldwide, cardiovascular manifestations of acute carbon monoxide (CO) poisoning have been subject of various studies but current evidence about effects of chronic CO exposure on atherosclerosis is limited which is very common. We aimed to investigate association of chronic CO exposure with atherosclerosis by measuring carotid intima-media thi...

STUDY OBJECTIVE The purpose of this study was to evaluate the reliability of noninvasive real-time measurement of carboxyhemoglobin (COHb) using a pulse CO-oximeter in victims of carbon monoxide poisoning (COP). METHODS During the 7-month study period, pulse CO-oximetry was measured on patients admitted to the emergency department (ED) for suspected COP. Each patient included in the study und...