This study aimed to evaluate the clinical outcomes of patients with mucoepidermoid carcinomas in the head and neck treated with carbon-ion radiotherapy. Data from 26 patients who underwent carbon-ion radiotherapy in four facilities were analyzed in this multi-institutional retrospective study: the Japan Carbon-ion Radiation Oncology Study Group. The median follow-up time was 34 months. One pati...

The Hyogo Ion Beam Medical Center was constructed in 2001 as the world's first charged particle radiotherapy center where both proton and carbon-ion radiotherapy can be performed. From April 2001 to February 2007, more than 1,400 patients with a variety of cancers were treated. Most of the tumors except for prostate cancer were considered hard to cure with standard treatments such as surgery or...

The carbon-ion radiotherapy (RT) with HIMAC has been conducted since 1994, and the accumulated number of patients treated exceeded 7,500 in July 2013. On the basis of the HIMAC experience, NIRS developed a compact carbon-ion RT facility in order to boost the carbon-ion RT in Japan, and a pilot facility of this work was constructed and conducted at the Gunma University. Toward the further develo...

Carbon-ion radiotherapy (CIRT) has progressed rapidly in technological delivery, indications, and efficacy. Owing to a focused dose distribution in addition to high linear energy transfer and subsequently high relative biological effect, CIRT is uniquely able to target otherwise untreatable hypoxic and radioresistant disease while opening the door for substantially hypofractionated treatment of...

Radiotherapy using charged and/or high-LET particles has a long history, starting with proton beams. In vitro data clarify that RBE (Relative Biological Effectiveness) increases with LET up to approximately 150 keV/μm for carbon-12 and neon-20 ions. In vivo studies show that tumor control probabilities after single doses of gamma rays shift to higher doses when tumors were irradiated with 5-fra...

In the three therapy beam times 2007 about 50 patients were planned and treated with our treatment planning software, TRiP98, and its development version, TRiP98BEAM. In the past, the standard method was to optimize the biological target dose distribution for the contributing partial fields singly. Due to the enormous effort for the computation of biological effects, only a simple, but still su...

Carbon-ion radiotherapy (C-ion RT) possesses physical and biological advantages. It was started at NIRS in 1994 using the Heavy Ion Medical Accelerator in Chiba (HIMAC); since then more than 50 protocol studies have been conducted on almost 4000 patients with a variety of tumors. Clinical experiences have demonstrated that C-ion RT is effective in such regions as the head and neck, skull base, ...

STUDY OBJECTIVES The purpose of this study was to investigate the effect of heavy-ion radiotherapy on pulmonary function in patients with clinical stage I non-small cell lung cancer (NSCLC) patients. DESIGN Retrospective study. SETTING Research Center Hospital for Charged Particle Therapy, National Institute of Radiological Sciences, Chiba, Japan. PATIENTS From a total of 81 patients who ...

A high-energy carbon-ion radiotherapy facility is under construction at Gunma University Heavy Ion Medical Centre (GHMC). Its design was based on a study of the heavy ion radiotherapy at the National Institute of Radiological Sciences (NIRS) in order to reduce the size and construction cost of the facility. A compact electron cyclotron resonance ion source (ECRIS) for Gunma University, called K...