نتایج جستجو برای: carbamylation

تعداد نتایج: 238  

2015
Christiane Drechsler Sahir Kalim Julia B. Wenger Pirianthini Suntharalingam Tammy Hod Ravi I. Thadhani S. Ananth Karumanchi Christoph Wanner Anders H. Berg

Serum carbamylated albumin (C-Alb) levels are associated with excess mortality in patients with diabetic end-stage renal disease. To gain insight into the pathophysiology of carbamylation, we determined associations between C-Alb and causes of death in patients on chronic hemodialysis. The Die Deutsche Diabetes Dialyse Studie (4D study) was a randomized controlled trial testing the effects of a...

Journal: :Plant physiology 2000
S A Ruuska T J Andrews M R Badger G D Price S von Caemmerer

Leaf metabolites, adenylates, and Rubisco activation were studied in two transgenic tobacco (Nicotiana tabacum L. cv W38) types. Plants with reduced amounts of cytochrome b/f complex (anti-b/f) have impaired electron transport and a low transthylakoid pH gradient that restrict ATP and NADPH synthesis. Plants with reduced glyceraldehyde 3-phosphate dehydrogenase (anti-GAPDH) have a decreased cap...

2015
Thushara Chakkath Sidonie Lavergne Timothy M. Fan David Bunick Levent Dirikolu

DNA Alkylation is thought to be the reason for the efficacy of lomustine while carbamylation has been implicated as the cause for the side effects seen with lomustine treatment such as hepatotoxicity. In the alkylation study we show that lomustine and its metabolites form similar levels of the DNA adducts N⁷ hydroxyethylguanine and O⁶ hydroxyethyldeoxyguanosine. In terms of carbamylation, lomus...

Journal: :Journal of the American Society of Nephrology 2013

Journal: :Clinical science 2009
Sanjeev Sirpal

There is an emerging and significant body of research that suggests that MPO (myeloperoxidase) may be a critical mediator in dysfunctional lipoprotein formation and, hence, atherogenic initiation and progression. MPO is a haem peroxidase found in leucocytes and is abundant in macrophages surrounding atherosclerotic lesions. Several lines of evidence support the role of MPO-mediated carbamylatio...

Journal: :Journal of the American Society of Nephrology : JASN 2013
Robert A Koeth Kamyar Kalantar-Zadeh Zeneng Wang Xiaoming Fu W H Wilson Tang Stanley L Hazen

Traditional risk factors fail to explain the increased risk for cardiovascular morbidity and mortality in ESRD. Cyanate, a reactive electrophilic species in equilibrium with urea, posttranslationally modifies proteins through a process called carbamylation, which promotes atherosclerosis. The plasma level of protein-bound homocitrulline (PBHCit), which results from carbamylation, predicts major...

Journal: :Proceedings of the National Academy of Sciences 2015

Journal: :Biochimica et biophysica acta 1997
E Perola L Cellai D Lamba L Filocamo M Brufani

Heptylphysostigmine is in advanced clinical trial as a drug for Alzheimer's disease. 8-Morpholinooctylphysostigmine and 8-(cis-2,6-dimethylmorpholino)octylphysostigmine are currently undergoing pre-clinical evaluation. The mechanism of action of these compounds in the inhibition of acetylcholinesterase has been investigated. All the examined compounds display non competitive-like kinetics of in...

2015
Ger J. M. Pruijn

The discovery that citrullination was crucial for the recognition of antigens by the most disease-specific class of autoantibodies in rheumatoid arthritis (RA) had a huge impact on studies aimed at understanding autoimmunity in this disease. In addition to the detailed characterization of anti-citrullinated protein antibodies, various studies have addressed the identity of citrullinated antigen...

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