The Home Office Police Research Group (PRG) was formed in 1992 to carry out and manage research relevant to the work of the police service and Home Office Policy Divisions. One of the major police department divisions which acts as customer for the PRG is the Home Office Crime Prevention Unit which was formed in 1983 to promote preventative action against crime. It has a particular responsibili...

conclusions the os trigonum syndrome should take in consideration in elderly subject who had posterior ankle pain starting after a car accident. case presentation a 62-year-old female patient was admitted with load depended ankle pain and swelling, lasting for five years which promptly started after a car accident. we incidentally discovered os trigonum on plain radiography on a lateral view of...

conclusion the chances of sustaining serious spine and associated multiple injuries in car accidents are quite high in iran. this may be due to the low level of standards or car manufacturing, absence, or inadequacy of appropriate safety measures in cars, poorly designed roads, and problems in the quality of driving to mention just a few reasons. therefore, these victims are prone to significan...

Novel immunotherapeutic agents targeting tumor-site microenvironment are revolutionizing cancer therapy. Chimeric antigen receptor (CAR)-engineered T cells are widely studied for cancer immunotherapy. CD19-specific CAR-T cells, tisagenlecleucel, have been recently approved for clinical application. Ongoing clinical trials are testing CAR designs directed at novel targets involved in hematologic...

The constitutive androstane receptor (CAR) transactivation can occur in the absence of exogenous ligand and this activity is enhanced by agonists TCPOBOP and meclizine. We use biophysical and cell-based assays to show that increased activity of CAR(TCPOBOP) relative to CAR(meclizine) corresponds to a higher affinity of CAR(TCPOBOP) for the steroid receptor coactivator-1. Additionally, steady-st...

suspension system as one of the most important key elements of vehicle has always been considered by research centres and auto makers over the world and this issue is more important on sport cars which have special sensitive working conditions and even the smallest defect can strongly affect their performances. in this study, optimization of effective handling parameters of a sport car with thr...

background: seat belts have been proven as one of the most successful means of preventing or reducing injuries to occupants of cars during an accident. this paper examines the reasons behind the non-compliance of the seat belt law in malaysia and suggests possible measures to get the percentage of seat belt usage up higher. methods: various databases of articles were searched for seat belt usag...

background: driving posture discomfort can contribute to musculoskeletal disorders (msds), injuries, lumbar pain and fatigue. the three main objectives of this study were to identify the level of awareness for correct and safe driving posture, health implication to their body parts and to propose a suitable car seat fit dimensions appropriate for malaysian drivers’ population. methods: the two ...

The constitutive androstane receptor (CAR) NR1I3 is a transcription factor that upon activation by xenobiotics induces transcription of drug-metabolizing and drug transporter genes. Our goal was to identify whether alternative splicing of CAR makes an important contribution to the generation of novel CAR proteins. The wild-type CAR mRNA (CAR.1) and splice variants (SVs) were amplified from huma...

Coxsackie and adenovirus receptor (CAR) was first known as a virus receptor. Recently, it is also known to have tumor suppressive activity such as inhibition of cell proliferation, migration, and invasion. It is important to understand how CAR expression can be regulated in cancers. Based on an existence of putative Sp1 binding site within CAR promoter, we investigated whether indeed Sp1 is inv...