Capillary electrophoresis is a powerful separation technique that can achieve high efficiency separations of charged analytes. However, one limitation of capillary electrophoresis is the adsorption of cationic proteins and peptides onto the inner surface of the capillary wall, due to the negatively charged silanol groups on the bare fused silica capillaries. This can lead to poor separation eff...

deproteinisation with acetonitrile (along with methanol or other reagents) is a useful and rapid technique in analysis of drugs or their metabolites in human serum. in this paper application of this simple technique in biopharmaceutical analysis using capillary electrophoresis (ce) is evaluated. some drugs with different ionic and protein binding properties were selected and dissolved in human ...

An on-line coupled capillary isotachophoresis-capillary zone electrophoresis method for the determination of glycyrrhizin in liqueurs is described. The optimised electrolyte system was 5 mM HCl+11 mM epsilon-aminocaproic acid+0.05% hydroxyethylcellulose+30% methanol (leading electrolyte), 5 mM caproic acid+30% methanol (terminating electrolyte) and 20 mM caproic acid+10 mM histidine+0.1% hydrox...