After completing my medical education in the late 1950s, I started PhD studies at the University of Göteoorg, where Björn Folkow introduced me to cardiovascular research. His elegant studies on the functional organization of the autonomic nervous system and its control of peripheral vascular resistance were already dassics in cardiovascular physiology. Although several other vascular functions ...

This review leads us to a number of conclusions and suggestions for further study. First, we find wide differences in the meaning of flow heterogeneity, arising as a result of the different methods used. These differences will have to be reconciled to form a comprehensive view of the role of heterogeneity in determining vascular function. Second, in the future, the meaning of heterogeneity must...

The dynamic distribution of intravenously infused solutions between the plasma and the interstitial compartments was studied. A mathematical model developed to simulate infusion experiments considered transcapillary fluid and protein exchange, lymph flow, interstitial compliance, capillary surface area, and peripheral vascular resistance. The experimental arterial and venous blood pressure resp...

Activation of sympathetic adrenergic postganglionic fibers that release norepinephrine at the neuromuscular junction can influence resistance, capacitance, and exchange functions in the microcirculation. Although the predominant response is an increase in precapillary resistance that reduces blood flow through the tissue (at constant pressure perfusion), there are two distinct components that c...

Dynamic ligand exchange-affinity capillary electrophoresis (DLE-ACE) is introduced as a convenient platform for assessing the conformational stability and relative affinity of a holoprotein to different ligands without off-line sample pretreatment, since ligand exchange and protein unfolding processes are integrated in-capillary during electromigration.

THE objective of this article is to examine two complementary hypotheses that, together, describe the role of the intercellular junction in the regulation of capillary permeability. One hypothesis states that the permeability of capillaries with continuous endothelium is modulated by the area available for the diffusion of small solutes in the spaces between adjacent endothelial cells. The seco...

Major lung resection is a robust model that mimics the consequences of loss-of-functioning lung units. We previously observed in adult canines, following 42% and 58% lung resection, a critical threshold of stimuli intensity for the initiation of compensatory lung growth. To define the range and limits of this stimuli-response relationship, we performed morphometric analysis on the remaining lob...

Cardiac dysfunction of both systolic and diastolic origins leads to increased left atrial pressure, lung capillary injury and increased resistance to gas transfer. Acutely, pressure-induced trauma disrupts the endothelial and alveolar anatomical configuration and definitively causes an impairment of cellular pathways involved in fluid-flux regulation and gas exchange efficiency, a process well ...

Hsia, Connie C. W., Robert L. Johnson, Jr., and Dipen Shah. Red cell distribution and the recruitment of pulmonary diffusing capacity. J. Appl. Physiol. 86(5): 1460–1467, 1999.—The distribution of red blood cells in alveolar capillaries is typically nonuniform, as shown by intravital microscopy and in alveolar tissue fixed in situ. To determine the effects of red cell distribution on pulmonary ...