Breast cancer heterogeneity is evident at the clinical, histological and molecular level. High throughput technologies allowed the identification of intrinsic subtypes that capture transcriptional differences among tumors. A remaining question is whether said differences are associated to a particular transcriptional program which involves different connections between the same molecules. In ot...

Purpose Health insurers offer plans covering a narrow subset of providers in an attempt to lower premiums and compete for consumers. However, narrow networks may limit access to high-quality providers, particularly those caring for patients with cancer. Methods We examined provider networks offered on the 2014 individual health insurance exchanges, assessing oncologist supply and network partic...

Molecular signaling networks are believed to determine cancer robustness. Although cancer patient survivability was reported to correlate with the heterogeneous connectivity of the signaling networks inspired by theoretical studies on the increase of network robustness due to the heterogeneous connectivity, other theoretical and data analytic studies suggest an alternative explanation: the impa...

in wireless sensor networks, optimal consumptionof energy and having maximum life time are important factors. in this article attempt has been made to send the data packets with particular reliability from the beginning based on aodv protocol. in this way two new fields add to the routing packets and during routing and discovering of new routes, the lowest remained energy of nodes and route tra...

Due to its extraordinary heterogeneity and complexity, cancer is often proposed as a model case of a systems biology disease or network disease. There is a critical need of effective biomarkers for cancer diagnosis and/or outcome prediction from system level analyses. Methods based on integrating omics data into networks have the potential to revolutionize the identification of cancer biomarker...

Altered growth factor responses in phospho-protein-driven signaling networks are crucial to cancer cell survival and pathology. Profiles of cancer cell signaling networks might therefore identify mechanisms by which such cells interpret environmental cues for continued growth. Using multiparameter flow cytometry, we monitored phospho-protein responses to environmental cues in acute myeloid leuk...

Cancer Networks are responsible for the management of cancer services in England. They are, in principle, logical units for the analysis of cancer survival, since for most patients, the entire pathway of referral, diagnosis and treatment is likely to be contained within the territory of a Cancer Network. This study investigates the implications of using each patient's Cancer Network of residenc...