Small-conductance Ca2+-activated K+ (SK) channels are widely expressed in neuronal tissues where they underlie post-spike hyperpolarizations, regulate spike-frequency adaptation, and shape synaptic responses. SK channels constitutively interact with calmodulin (CaM), which serves as Ca2+ sensor, and with protein kinase CK2 and protein phosphatase 2A, which modulate their Ca2+ gating. By recordi...

conclusions this study revealed the noticeable popularity of cam in patients suffering from chronic rheumatologic diseases, mostly due to their dissatisfaction with conventional treatments. patients and methods in this cross-sectional study, 100 randomly selected patients, with different diseases, were questioned about demographic data, disease duration, the type of cam used, reasons, visit int...

CAM (Complementary and Alternative Medicine) therapies have become increasingly  popular in pediatric populations. phytotherapy are the most common CAM used in children. Yet, little is known about children’s preferences for CAM. But It is expected to become more widely integrated into the modern medical system, including the medical curriculum.The aim of this study is to introduce the prevalenc...

Using video, fluorescence and confocal microscopy, quantitative analysis and modeling, we investigated intracellular processes mediating the calcium/calmodulin (Ca(2+)/CaM)-dependent slow motility in hair cells dissociated from the rostral region of amphibian papilla, one of the two auditory organs in frogs. The time course of shape changes in these hair cells during the period of pretreatment ...

This paper develops a new approach to solve the problem of interferences during the flank milling of a non-developable ruled surface. Many articles propose to modify the tool path to reduce this problem. A novel approach is proposed here, Computation of Adapted Tool Shape (CATS), which computes and optimizes the tool shape to reduce these interferences. The aim of this CATS method is to maintai...

This report documents the clinical, radiographic, and histologic outcome of a custom-made computer-aided-design/computer-aided-manufactured (CAD/CAM) scaffold used for the alveolar ridge augmentation of a severely atrophic anterior mandible. Computed tomographic (CT) images of an atrophic anterior mandible were acquired and modified into a 3-dimensional (3D) reconstruction model; this was trans...

Presynaptic metabotropic glutamate receptors (mGluRs) often act as feedback inhibitors of synaptic transmission and serve important roles in defining the activity of glutamatergic synapses. Recent investigations have begun to identify novel interactions of presynaptic mGluRs, especially mGluR7, with multiple protein kinases and putative regulatory proteins that probably serve to further shape t...

an increasing number of asthmatic patients are attracted by complementary and and alternative medicine (cam). the aim of this study was to estimate the prevalence and describe the characteristics of cam use by children with asthma in a paediatric allergy clinic in istanbul, turkey.the parents of asthmatic children were invited to participate in a cross-sectional survey study. current asthma tre...

In a prior study of in ovo exogenous retinoic acid (RA) exposure, we observed a prolonged expression of cell surface N-CAM in cranial neural crest (NC) cells exhibiting migratory failure. In the present studies, we employed an experimental strategy in which embryos were first exposed to exogenous RA in ovo and incubated for 45-60 hr; this was followed by extirpation and in vitro culturing of th...

AIM Objective of the present study was to isolate bovine herpes virus Type 1 (BHV-1) from semen of infected bull and to adapt it onto embryonated eggs and Madin-Darby bovine kidney (MDBK) cell line. Further, the virus was identified by agar gel immunodiffusion (AGID) test. MATERIALS AND METHODS Semen samples were collected from five BHV-1 positive bulls previously confirmed for the presence o...