Astragalus membranaceus Bge. var. mongholicus (Bge.) Hsiao (A. mongholicus, family Leguminosae) is one of the most important traditional Chinese herbs because it contains lots of bioactive metabolites, which have beneficial and pharmacological effects on health. Simultaneously, it has been proved to be a salt-tolerant plant-one of the potential species to control the soil salinization. Therefor...

Identifying potent drug combination from a herbal mixture is usually quite challenging, due to a large number of possible trials. Using an engineering approach of the feedback system control (FSC) scheme, we identified the potential best combinations of four flavonoids, including formononetin, ononin, calycosin, and calycosin-7-O- β -D-glucoside deriving from Astragali Radix (AR; Huangqi), whic...

A new simple and efficient RP-HPLC-UV method was developed for the simultaneous analysis of nine isoflavonoids in Huangqi-Gegen herbal pair. Effective chromatographic separation of these components was achieved on a Kromasil C18 column (4.6×250 mm, i.d.; 5 μm) with gradient elution of methanol and 0.2% formic acid aqueous solution at a flow rate of 1.0 mL/min in 60 min. Detection was performed ...

Cicer arietinum, Ascochyta rabiei, Elicitor. Isoflavones, Phytoalexins Upon slicing cotyledons of chickpea, Cicer arietinum L ., accumulate the pterocarpan phyto­ alexins medicarpin and maackiain. Treatment of this tissue with an elicitor from the phytopathogenic deuteromycete Ascochyta rabiei (Pass.) Lab. greatly enhances accumulation of the pterocarpans and of other isoflavones and flavonoids...

OBJECTIVE To more scientifically and reasonably control the quality of Huangqi Granules, preliminary studies on the pharmacodynamics and serum pharmacochemistry of this medicine were performed. DPPH and MTT experiments showed that water extracts of Huangqi Granules had good antioxidant activity and increased immunity. Timed blood samples collected 5 min, 15 min, and 30 min after oral administra...

Rheumatoid arthritis (RA) is a systemic inflammatory disorder that can cause destructive joint disease, significant disability, and increased mortality. RA the most frequent of all chronic diseases, its prevalence frequency in Pakistan 1.6 per thousand people. Different cytokines receptors were involved triggering RA, including interleukin-6 (ILR-6), major histocompatibility complex (MHC) antig...

Abstract Gout has become a global problem, antiuric acid formula (AAF) is clinical prescription highly effective in reducing uric levels. In order to find its quality control standards and contribute the treatment of gout future, we adopted high-performance liquid chromatography orbitrap chromatography–mass spectrometry establish fingerprints 13 batches AAF. The different AAF were tested activi...

BACKGROUND Macrophage infiltration in adipose tissue together with the aberrant production of pro-inflammatory cytokines has been identified as the key link between obesity and its related metabolic disorders. This study aims to isolate bioactive ingredients from the traditional Chinese herb Radix Astragali (Huangqi) that alleviate obesity-induced metabolic damage through inhibiting inflammatio...