Skeletal muscle uncoupling protein 2 and 3 (UCP-2 and UCP-3) mRNA levels are increased during calorie restriction in lean and nondiabetic obese subjects. In this work, we have investigated the effect of a 5-day hypocaloric diet (1,045 kJ/day) on UCP-2 and UCP-3 gene expression in the skeletal muscle of type-2 diabetic obese patients. Before the diet, UCP-2 and UCP-3 mRNA levels were more abunda...

Calorie restriction is a common strategy for weight loss in obese individuals. However, little is known about the impact of moderate hypocaloric diets on obesity-related laboratory parameters in a short-term period. Aim of this study was to evaluate the variation of laboratory biomarkers in obese individuals following a Mediterranean, hypocaloric (1400-1600 Kcal/die) diet. 23 obese, pharmacolog...

Calorie restriction can inhibit or delay carcinogenesis, reportedly due to a reduction in calorie intake rather than by concurrent changes in body mass and/or composition. Our objective was to test the hypothesis that body mass and/or composition have an important effect, independent of energy intake, on the benefits or hazards associated with calorie restriction or overeating, respectively. In...

The purpose of this research was to compare the influence of calorie restriction by removal of fat with calorie restriction by removal of carbohydrate on the promotion of skin tumorigenesis in mice. Female SENCAR mice were initiated with 7,12-dimethylbenz(a)anthracene (10 nmol, single topical treatment) and fed calorie-restricted diets during and following promotion with 12-O-tetradecanoylphorb...

Background: In addition to reducing body weight, the low-calorie diets can reduce the lean body mass. It is hypothesized that in addition to reducing the body weight, the low-calorie diets can maintain the lean body mass. So, the current study aimed at evaluating the effects of high-protein diet with calorie restriction on body composition in overweight and obese individuals. Methods: 36 obese ...

Recent studies of calorie restriction in several organisms demonstrate an increase in mitochondrial activity that is associated with the salutary effects of this dietary restriction regimen. In this Essay, I speculate on how an increase in mitochondrial activity might provide benefit and discuss how diet, mitochondria, and sirtuins might interact in a pathway to slow aging and associated diseases.

Longevity in Okinawa is considered to be a result of traditional low calorie diet. Le Bourg suggests that Okinawa is an example of severe malnutrition, which is harmful for later generations. We believe that current loss of longevity advantage in Okinawa is a result of diet westernization and that the dietary restriction is a valid way of life extension in humans.

introduction: fasting, like islamic ramadan fasting, has been associated with health benefits. islamic ramadan fasting, a form of caloric restriction (cr) or alternate day fasting that. studies suggest a comparable effect of adf and caloric restriction. despite the fact that fasting can be considered as a form of dietary restriction, fasters tend to have difficulty to reduce their food intake d...

Although calorie restriction and alternate-day fasting have potential for slowing the aging process while decreasing risk for vascular disease, diabetes, cancer and dementia, a “carbohydrate-concentrated” diet strategy, entailing long daily periods of carbohydrate abstinence, may prove to be a much more practical strategy for achieving these aims. The life extension and healthy aging benefits o...

It is well known that immunological functions are influenced by stressors . Psychological stressors influence also usual behaviors such as eating, sleep and exercise . In this paper, we report effects of emotional behavior, restriction, sleep deprivation or nutrition on immunological functions using animal model. Using mature cats which were implanted electrode in hypothalamus, emotional behavi...