There is wide variation in how patients respond to therapeutics. Factors that contribute to pharmacokinetic variations include disease, genetics, drugs, age, and diet. The purpose of this study was to determine the effect of calorie restriction on the expression of Abcb1a in the intestine and whether calorie restriction can alter the absorption of an Abcb1a substrate (i.e., digoxin) in mice. Te...

1. We investigated the effects of the chronic administration of a sympathomimetic agent on energy expenditure, protein metabolism and levels of thyroid hormones and catecholamines in 10 obese subjects after a 6-week very-low-calorie-diet programme (1965 kJ, 60 g of protein, 45 g of carbohydrates). L-(-)-Ephedrine hydrochloride (50 mg three times a day by mouth) or placebo were administered duri...

Diet carbonated soft drinks were introduced to help consumers lower caloric intake. However, critics suggest that these can provide an excuse consume more calories, a so-called “Big Mac and Coke” mentality is consistent with behavioral theories such as moral licensing (e.g., combining healthy eating choice indulgent, less one). Using individual-level food drink consumer panel data from major fa...

BACKGROUND Cardiovascular disease remains the leading cause of death and disability in industrialized and developing countries. The aim of this research was to determine the effect of rice bran oil, with a low-calorie diet, on lipid profiles, in hyperlipidemic patients. MATERIALS AND METHODS This study was a parallel groups' randomized clinical trial with a pre- and post-test design. Fifty hy...

To investigate the inhibitory effect of dietary calorie restriction on experimental autoimmune uveoretinitis (EAU) in rats, and its mechanism. Lewis rats were maintained on a 50% calorie-restricted diet for 2 months or 6 months. The control group was maintained on a 90% ad libitum intake for the same length of time. Experimental autoimmune uveoretinitis was elicited in both groups by immunizati...

The most popular and successful way to maintain a healthy body is have rich balanced diet combined with physical exercise. Since the dilemma was proposed, several works in literature suggested calculating that respects nutritional needs of each person. In Caloric-Restricted Diet Problem (CRDP), goal find reduced-calorie meets these needs, enabling weight loss. This paper proposes an Island-Base...

BACKGROUND Research has shown micronutrient deficiency to be scientifically linked to a higher risk of overweight/obesity and other dangerous and debilitating diseases. With more than two-thirds of the U.S. population overweight or obese, and research showing that one-third are on a diet at any given time, a need existed to determine whether current popular diet plans could protect followers fr...

BACKGROUND Childhood obesity has been recognized as the new epidemic in developed countries. Caloric restriction with physical activity is the main therapeutic treatment available for these children. We compared two different dietary protocols to assess treatment efficacy. METHODS Obese children from the Pediatric Endocrinology clinic were prospectively recruited for the study. Children and t...

Significant reductions in insulin resistance (IR) can be achieved by either calorie restriction or by the increase of lean mass. However, calorie restriction usually results in significant loss of lean mass. A 6-week randomized controlled feeding trial was conducted to determine if a calorie-restricted, high-protein diet (~125 g protein/day consumed evenly throughout the day) using novel functi...