BACKGROUND MicroRNAs (miRNAs) are a class of small non-coding RNAs, which post-transcriptionally repress the expression of genes involved in cancer initiation and progression. Although some miRNAs that target many signaling pathways (also called universe miRNAs) are supposed to play a global role in diverse human tumors, their regulatory functions in gynecological cancers remain largely unknown...

Lattice surgery is a measurement-based technique for performing fault-tolerant quantum computation in two dimensions. When using the surface code, most general lattice operations require irregularities called twist defects. However, implementing twist-based may additional resources, such as extra device connectivity, and could lower threshold overall performance code. Here we provide an explici...

The Octant Rule1 provides a theoretical basis for the study of optical rotatory dispersion curves of ketones. The application of this rule to extensive collections of data for cyclohexanone types from our two laboratories has been described elsewhere.2 3 Among the hundreds of curves recorded, a few stand out by reason of their unusually large amplitudes (positive or negative), which cannot be r...

This paper focuses on mechanical aspects of chromatin biological functioning. Within a basic geometric modeling of the chromatin assembly, we give a complete set of elastic constants (twist and bend persistence lengths, stretch modulus and twist-stretch coupling constant) of the so-called 30-nm chromatin fiber, in terms of DNA elastic properties and geometric properties of the fiber assembly. T...

using qcd factorization for the hadronic matrix elements, we show that existing data, inparticular the branching ratios br ( b →j/ψk) and br ( b →j/ψπ), can be accounted for in this approach.we analyze the decay b j /k( ) within the framework of qcd factorization. the calculation of therelevant hard-scattering kernels for twist-2 and twist-3 is completed. we calculate this decay in a special...

Knots in R which may be parameterized by a single cosine function in each coordinate are called Lissajous knots. We show that twist knots are Lissajous knots if and only if their Arf invariants are zero. We further prove that all 2-bridge knots and all (3, q)-torus knots have Lissajous projections.

Vortex extrusion (VE) is a severe plastic deformation technique which is based on the synergies between high strain accumulation and high hydrostatic pressure. Such a high amount of pressure, places a mandate to seek the method for investigation of the load under processing conditions. For this, kinematically admissible velocity field and upper bound terms based on Bezier formulation are develo...

Twist extrusion process is a rather new route to produce highly strained materials. In this process, severe plastic deformation is applied by large shear strains. In current article, required energy for twist extrusion by use of admissible velocity field together with the upper bound technique is predicted. The proposed model is capable of considering the effect of various parameters such as di...