Caenorhabditis elegans (C. elegans) is a model organism for understanding aging and studying animal behavior. Microfluidic assay techniques have brought widespread advances in C. elegans research; however, traditional microfluidic assays such as those based on soft lithography require time-consuming design and fabrication cycles and offer limited flexibility in changing the geometric environmen...

We present a novel method of targeted gene disruption that involves direct injection of recombinant Cas9 protein complexed with guide RNA into the gonad of the nematode Caenorhabditis elegans. Biallelic mutants were recovered among the F1 progeny, demonstrating the high efficiency of this method.

Innate immunity is an evolutionary ancient defence strategy that serves to eliminate infectious agents while maintaining host health. It involves a complex network of sensors, signaling proteins and immune effectors detect the danger, then relay execute programme. Post-translational modifications relying on conserved ubiquitin ubiquitin-like are integral part system. Studies using invertebrate ...

Caenorhabditis elegans (C. elegans), a member of the phylum Nematoda, carries the evolutionarily conserved genes comparing to mammals. Due to its short lifespan and completely sequenced genome, C. elegans becomes a potentially powerful model for mechanistic studies in human diseases. In this mini review, we will outline the current understandings on C. elegans as a model organism for microRNA (...

Sinirbilim, milyonlarca nöron ve milyarlarca sinapstan oluşan insan beyninin yapı fonksiyonlarını anlamaya çalışır. Laboratuvar ortamında böylesine gelişmiş bir sistem için model oluşturmak incelemek mümkün değildir. Yirmi yılı aşkın süredir, sinir sistemine benzer özellikleri kolay incelenebilir yapısı nedeniyle Caernohabditis elegans (C. elegans), nöral ağların davranışını anlamak faydalı ola...