conclusions according to this observation, another factor such as oncogenes activity may cause cancer in samples but ct genotype of mthfr can be considered as an effective factor in creating cancer. results methylation status of e-cadherin gene numbers of methylated cases in the cancer group were equal to one and unmethylated cases equal to 33 and numbers of unmethylated cases in the non-cancer...

Background & Objective: Epithelial-Mesenchymal transition (EMT) is known to be a possible mechanism in tumor progression; however, there insufficient evidence support the contribution of this process human cancers. The present study aimed evaluate expression EMT markers normal oral epithelium and squamous cell carcinoma also correlates with some clinicopathological parameters.Methods: This was ...

This study aims to explore the role of YKL-40 on permeability vessels in mice model and HDMECs histamine induces vascular hyperpermeability. The expression a HMC-1 was detected by RT-PCR western blot. experiment divided into different concentrations (10, 100 500ng/ml) alone,different concentrations(10, 500 ng/ml) YKL-40+100 μM histamine,500ng/ml YKL-40+100μM histamine+10 loratadine,100 alone bl...

Malignant transformation of melanocytes frequently coincides with alterations in epithelial cadherin (E-cadherin) expression, switching on of neural cadherin (N-cadherin), and, when progressed to a metastatic stage, loss of membranous placental cadherin (P-cadherin). In vitro studies of melanoma cell lines have shown invasion suppressor and promoter roles for E-cadherin and N-cadherin, respecti...

Cell alignment is critical in numerous areas, from tissue engineering to biohybrid robotics. modulated through many features including surface topographies, mechanical cues cell-matrix interactions, and cell-cell interactions. In this study, we present our approach examine the role of topographies interactions with respect cell alignment. We developed an create wavy at nanometer size scale, whi...

The purpose of the present study was to identify histological biomarkers that could be used predict adipose tissue invasion by oral squamous cell carcinoma (OSCC). medical records and preoperative computed tomography scans patients with primary OSCC suspected buccal fat pad were retrospectively reviewed, an immunohistochemical candidate predictive (α-SMA, E-cadherin, N-cadherin, FABP4, Col VI, ...

Invasive breast carcinoma berdasarkan gene profiling dibagi menjadi beberapa subtipe.Salah satunya adalah Triple negative cancer (TNBC). TNBC sering menginvasi stroma ataupun bermetastasis ke KGB aksila yang berpengaruh terhadap rekurensi dan kematiandisebabkan karena hilangnya adhesi sel satu lain transisi dari epitelial mesenkim ( Epithelial–mesenchymal transition/EMT). Adhesi antar diatur ol...