This study aims to explore the role of YKL-40 on permeability vessels in mice model and HDMECs histamine induces vascular hyperpermeability. The expression a HMC-1 was detected by RT-PCR western blot. experiment divided into different concentrations (10, 100 500ng/ml) alone,different concentrations(10, 500 ng/ml) YKL-40+100 μM histamine,500ng/ml YKL-40+100μM histamine+10 loratadine,100 alone bl...

Malignant transformation of melanocytes frequently coincides with alterations in epithelial cadherin (E-cadherin) expression, switching on of neural cadherin (N-cadherin), and, when progressed to a metastatic stage, loss of membranous placental cadherin (P-cadherin). In vitro studies of melanoma cell lines have shown invasion suppressor and promoter roles for E-cadherin and N-cadherin, respecti...

Cell alignment is critical in numerous areas, from tissue engineering to biohybrid robotics. modulated through many features including surface topographies, mechanical cues cell-matrix interactions, and cell-cell interactions. In this study, we present our approach examine the role of topographies interactions with respect cell alignment. We developed an create wavy at nanometer size scale, whi...

The purpose of the present study was to identify histological biomarkers that could be used predict adipose tissue invasion by oral squamous cell carcinoma (OSCC). medical records and preoperative computed tomography scans patients with primary OSCC suspected buccal fat pad were retrospectively reviewed, an immunohistochemical candidate predictive (α-SMA, E-cadherin, N-cadherin, FABP4, Col VI, ...

Invasive breast carcinoma berdasarkan gene profiling dibagi menjadi beberapa subtipe.Salah satunya adalah Triple negative cancer (TNBC). TNBC sering menginvasi stroma ataupun bermetastasis ke KGB aksila yang berpengaruh terhadap rekurensi dan kematiandisebabkan karena hilangnya adhesi sel satu lain transisi dari epitelial mesenkim ( Epithelial–mesenchymal transition/EMT). Adhesi antar diatur ol...

Background: Hyperuricemia contributes to kidney injury, characterized by tubular injury with epithelial–mesenchymal transition (EMT). Wnt5a/Ror2 signaling drives EMT in many kidney pathologies. This study sought to evaluate the involvement of Wnt5a/Ror2 in hyperuricemia-induced EMT in kidney tubular injury.Methods: A hyperuricemia model was performed in male Swiss background mice (3 months old,...

In many carcinomas, E-cadherin is considered to be a prognostic marker for patient survivals, and its decreased expression is associated with metastatic disease. Among renal cell carcinomas (RCCs), however, only 20% of tumors express E-cadherin, whereas a much higher percentage express other cadherins, e.g., N-cadherin and cadherin-6 (T. Shimazui et al, Cancer Res., 56: 3234-3237, 1996). Among ...