We previously discovered the implication of membrane-type 5-matrix metalloproteinase (MT5-MMP) in Alzheimer's disease (AD) pathogenesis. Here, we shed new light on pathogenic mechanisms by which MT5-MMP controls processing amyloid precursor protein (APP) and fate beta peptide (Aβ) as well its C99, C83. found human embryonic kidney cells (HEK) carrying APP Swedish familial mutation (HEKswe) that...

Background: Alzheimer’s disease (AD) is caused by accumulation of Ab, which is produced through sequential cleavage of b-amyloid precursor protein (APP) by the b-site APP cleaving enzyme (BACE1) and c-secretase. Enoxaparin, a low molecular weight form of the glycosaminoglycan (GAG) heparin, has been reported to lower Ab plaque deposition and improve cognitive function in AD transgenic mice. Met...

A widespread method for nowand forecasting economic macro level parameters such as GDP growth rates are survey-based indicators which contain early information in contrast to official data. But surveys are commonly affected by nonresponding units which can produce biases if these missing values can not be regarded as missing at random. As many papers examined the effect of nonresponse in indivi...

ABSTRACT This text aims to present the methodology of study of land-use conflicts performed in recent years by a multidisciplinary team, and to reveal the methods of survey and data collection, as well as the structure of the resulting database. We first define the scope of our study by providing a definition of these conflicts, of their characteristics and motives, of the ways they manifest th...

Access to formal financial services is a key determinant of inclusion and yet, informal mechanisms still dominate the system in developing countries. In this context, purpose our article investigate how growing effort harness mobile money designed for unbanked individuals may help overcome barriers access services. Using unique dataset obtained from an individual-level survey conducted Burkina ...

Selective control over Aβ production via γ-secretase modulators (GSM) is a promising strategy for treating Alzheimer's disease, yet the specific binding sites and mechanism of action GSMs remain unknown. Using recent cryo-electron microscopy structures substrate-bound we used two distinct methods to identify four potential pyridopyrazine-1,6-dione GSMs. We demonstrate site 4 formed between PS1-...