Ruegg et al. (1959) and Linn et al. (1959) have reported that rat liver contains two ubiquinones with C46 and C50 side chains (coenzymes Q, and Qlo respectively), the former predominating. Experiments in this Laboratory confirmed the presence of both these ubiquinones in our stock-colony rats and also showed the presence of traces of ubiquinones with side chains containing 40 and 35 carbon atom...

Thimet oligopeptidase is a metalloenzyme involved in regulating neuropeptide processing. Three cysteine residues (246, 248, 253) are known to be involved in thiol activation of the enzyme. In contrast to the wild-type enzyme, the triple mutant (C246S/C248S/C253S) displays increased activity in the absence of dithiothreitol. Dimers, purportedly formed through cysteines 246, 248 and 253, have bee...

Danggui Buxue Tang (DBT) is a Traditional Chinese Medicine (TCM) formula primarily used to treat symptoms associated with menopause in women. Usually, DBT is composed of one portion of Radix Angelicae Sinensis (RAS) and five portions of Radix Astragali (RA). Clinically, Radix Hedysari (RH) is sometimes used by TCM physicians to replace RA in DBT. In order to verity whether the chemical constitu...

lung disease will have met patients who fail to improve until the purulence of the sputum improves, either with time or with a change in antibiotic. In order to quantify changes in sputum purulence, this writer has for many years used an arbitrary grading system, historically called the TG system. It has a range from TG0 (white sputum) to TG4 (dark green sputum). With practice it is fairly easy...

Eukaryotic cells possess a unique way to communicate with each other by passing metabolites and small molecules through protein pores that connect adjacent cells. Although there are many types and families of protein pores, connexins comprise a unique family. Six connexin monomers assemble into a hemichannel, which is transported to the cell membrane. An opposing cell membrane containing compat...

During bacterial infection, hematopoietic stem and progenitor cells (HSPCs) differentiate into polymorphonuclear leukocytes (PMNs) in the bone marrow. We reported that HSPCs recruited to Staphylococcus aureus-infected skin wounds in mice undergo granulopoiesis, whereas other authors have demonstrated their differentiation in vitro after Toll-like receptor 2 (TLR2)/MyD88 stimulation. Here, we ex...

TOPIC: Critical Care TYPE: Medical Student/Resident Case Reports INTRODUCTION: The formation of a bronchopleural fistula (BPF) is rare but known complication following major thoracic surgery. In study by Nachira et al. looking at 835 patients in Italy who underwent lung resection, 786 lobectomy with 11 (1.3%) developing BPF [1]. other studies their incidence has been reported between 0.5-3% [2]...

position -4 C50 C49 C48 C47 C46 C45 C44 C43 C42 C41 C40 C39 C38 C37 C36 C35 C34 C33 C32 C31 C30 C29 C28 C27 C26 C25 C24 C23 C22 C21 C20 C19 C18 C17 C16 C15 C14 C13 C12 C11 C10 C9 C8 C7 C6 C5 C4 C3 C2 C1 C0 C-index SD P-value mark A 5 7 9 1 8 4 6 2 1 4 8 7 6 9 3 4 3 7 15 10 6 6 9 3 2 5 3 6 8 9 6 3 5 7 7 10 4 7 7 8 5 5 8 2 2 3 1 2 5 5 9 0.618 0.317 8.27E-03 n.s. A C 3 1 2 0 2 3 3 1 1 2 1 7 4 9 1 ...

Electrochemical studies on [ R ~ ( ~ ~ B U , P ) ( C O ) ~ ] ~ have shown that upon reduction in THF it undergoes an ECE-type mechanism, a chemical reaction coupled between two electron-transfer reactions, to form a dianion. The chemical step is a geometric isomerization, producing an isomer which is more easily reduced than the parent compound. Oxidation of the dianion back to the neutral comp...