The combination of pyridyl ligands and square-planar Pd(ii) or Pt(ii) cations has proven to be a very reliable recipe for the realization of supramolecular self-assemblies. This tutorial review deals with the design, synthesis and host-guest chemistry of discrete coordination cages built according to this strategy. The focus is set on structures obeying the formula [PdnL2n] (n = 2-4). The most ...

Twentyeight fatty aclds (C8:O to C24:ln-9) were measured by gas chromattography In four normal cell lines (C3H/lOT1/2, CCD18Co, CCD25SK and CCD 37Lu) an# seven cancer cell llnes ( M I , Caov-3, LS-180, PC3, SK-MEL-28, SK-MES-l and U-87 MG). Results show that C20:4 n-6, C24:0, C24:l n-9, Polyunsaturated fatty aclds (PUFA'S) and ratlos of C20:4 n-6 to C20:5 m3 and C16:O to C18:l n-9 and steatlc t...

Introduction Ionic liquids are a class of novel solvents with extremely high polarity [1]. Immobilization of organometallic complexes in thin films of supported ionic liquid has recently been suggested as a novel concept to combine the high selectivity of homogeneous catalysts with the easy separation of a heterogeneous system [2]. First catalytic studies show a high potential of these systems ...

There is considerable interest in exploiting metallosupramolecular cages as drug delivery vectors. Recently, we developed a [Pd2L4](4+) cage capable of binding two molecules of cisplatin. Unfortunately, this first generation cage was rapidly decomposed by common biologically relevant nucleophiles. In an effort to improve the kinetic stability of these cage architectures here we report the synth...

Neutral or cationic arene ruthenium complexes providing both hydrophilic as well as hydrophobic properties due to the robustness of the ruthenium-arene unit hold a high potential for the development of metal-based anticancer drugs. Mononuclear arene ruthenium complexes containing P- or N-donor ligands or N,N-, N,O- or O,O-chelating ligands, dinuclear arene ruthenium systems with adjustable orga...

The in vitro effect of recombinant human bone morphogenetic protein-2 (rhBMP-2) on osteogenic and myogenic differentiation was examined in two clonal cell lines of rat osteoblast-like cells at different differentiation stages, ROB-C26 (C26) and ROB-C20 (C20). The C26 is a potential osteoblast precursor cell line that is also capable of differentiating into muscle cells and adipocytes; the C20 i...

The modulation of the activity tyrosine kinases (TK) is an appealing topic current research. This work presents new pseudopeptidic cages that protect substrates from action TK enzyme, precluding corresponding Tyr phosphorylation, with a very good correlation between caging and kinase inhibition. results illustrate how signaling can be efficiently selectively modulated supramolecular complexes. ...