Immunization of BALB/c mice with nuclease leads to the production of anti-nuclease antibodies bearing a set of cross-reactive idiotypes (Id) distinct from those produced by B10.D2 mice after similar immunization. In both strains, such immunization with nuclease also leads to the production of splenic T helper cells (TH), which provide nuclease-specific help in an in vitro plaque-forming cell re...

the current treatment of choice for cutaneous leishmaniasis is either parenteral or intralesional antimonial compounds. each of these treatments has its own downfalls which include toxic side effects with the parentral injection and pain at the site of injection with the intralesional injection. in recent years, there has been more focus on paromomycin as an alternative drug; however, current d...

background: recent circumstantial evidences are suggesting that an increasing number of iranian patients with cu­taneous leishmaniasis are unresponsive to meglumine antimoniate (glucantime®). pistacia atlantica is native plant in iran (central, western, and eastern regions). gum obtained pistacia atlantica has been reported to possess consid­erable in vitro antimicrobial activity. in this study...

background: leishmaniasis is a vector-borne disease caused by flagellated protozoan parasites of the genus leishmania, which affects both humans and other mammals. most of the available drugs against the disease are toxic and some are parasite resistance to them. objective: the purpose of this study was to examine the effect of mespilus germanica extract on cutaneous leishmaniasis (cl) in balb/...

hedera helix  is widely used to treat bronchial asthma for many years. however, effects of this herb on lung histopathology is still far from clear. we aimed to determine the effect of oral administration of hedera helix on lung histopathology in a murine model of chronic asthma. balb/c  mice  were  divided  into  four  groups;   i  (placebo),  ii  (hedera  helix), iii (dexamethasone) and iv (c...