Hydrophobic interactions, based on cell surface hydrophobicity (CSH), are among the many and varied mechanisms of adherence deployed by the pathogenic yeast Candida albicans. Recently it was shown that, unlike C. albicans, C. dubliniensis is a species that exhibits an outer fibrillar layer consistent with constant CSH. Previously, C. dubliniensis grown at 25 or 37 degrees C was shown to coaggre...

The aim of the study was the determination of antifungal activity of N-3-(1,2,4-dithiazole-5-thione)-beta-resorcylcarbothioamide (DTRTA) against Candida albicans, non-Candida albicans, dermatophytes and molds and evaluation of the enzymatic activity C. albicans strains. We used reference strains C. albicans 10231 ATCC, 200 of C. albicans strains, 7 of non-C. albicans, 12 dermatophytes strains a...

The objective of this study was to evaluate whether Candida albicans exhibits altered pathogenicity characteristics following sublethal antimicrobial photodynamic inactivation (APDI) and if such alterations are maintained in the daughter cells. C. albicans was exposed to sublethal APDI by using methylene blue (MB) as a photosensitizer (0.05 mM) combined with a GaAlAs diode laser (λ 660 nm, 75 m...

Increasing rates of invasive candidiasis caused by non-albicans Candida species have been reported worldwide. Particular concerns have been raised for C. parapsilosis because of reduced in vitro susceptibility to echinocandins. We identified 212 patients with invasive candidiasis due to non-albicans Candida species (>or=5 cases per species) in 5 clinical trials of caspofungin monotherapy from t...

The effects of amphotericin B and fluconazole on the extracellular and intracellular growth of Candida albicans were studied. With respect to the extracellular growth of C. albicans, antifungal activity was measured in terms of MICs and minimal fungicidal concentrations as well as by determination of the concentration that effectively killed (greater than 99.9%) C. albicans in the absence or pr...

conclusions our findings indicate that resistance of c. albicans strains to azoles is more common in tokat, turkey. therefore, a strategy to control the inappropriate and widespread use of antifungal drugs is urgently needed. fungal culturing and antifungal susceptibility testing will be useful in patient management as well as resistance surveillance. materials and methods a total of 201 c. alb...

methods the mice were divided into six groups including a normal control group, a placebo group, and three treatment groups receiving 50, 100, and 200 mg/kg doses of hydroalcoholic extract via intraperitoneal (ip) injection followed by inoculation with c. albicans. a control+ group, inoculated only with c. albicans, was also employed. after all treatments, the mice were killed by cervical decap...

The role of Candida albicans yeast-to-hyphae transition in interleukin-12 (IL-12) production by monocytes was investigated. Germinating C. albicans not only failed to induce IL-12 p70 but also suppressed IL-12 production induced by heat-killed C. albicans. Comparison of the abilities of germinating C. albicans and agerminating mutants to inhibit IL-12 production showed that germination of C. al...